Table 2.

Thresholds for intervention with intravenous dextrose 5% in the context of sodium rise following tolvaptan dose

Rise in serum sodium	Time post-tolvaptan	Action
> 6 mmol/L	Within 6 h	Commence IV dextrose 5% at rate equivalent to urine output, continue to monitor frequently and cease when sodium back within target range
> 8 mmol/L	Within 12 h
> 10 mmol/L	Within 24 h	Aim for re-lowering with bolus hypotonic fluid