TABLE 2.

Pharmacokinetic parameters after oral administration of antibacterial agents (20 mg/kg) to hamsters with experimental pneumonia caused by M. pneumoniae FH

Fluid	Antibacterial agent	Cmax (μg/ml or g)	Tmaxa (h)	t1/2b (h)	AUC0–∞ (μg · h/ml or g)	Cmax/MICc	AUC0–∞/MICc
Serum	T-3811MEd	0.85	0.5	3.0	4.3	27.2	137
	Trovafloxacin	1.1	0.5	1.7	3.1	8.80	24.8
	Levofloxacin	2.2	0.5	2.0	8.4	4.40	16.8
	Clarithromycin	0.62	1	1.3	1.0	310	500
Lung	T-3811ME	2.1	1	2.4	7.7	67.1	246
	Trovafloxacin	1.6	0.5	1.1	3.5	12.8	28.0
	Levofloxacin	2.5	0.25	2.2	10.3	5.00	20.6
	Clarithromycin	9.6	1	2.3	27.5	4,800	13,750
BALF	T-3811ME	0.09	0.5	3.9	0.27
	Trovafloxacin	0.08	1	1.1	0.22
	Levofloxacin	0.17	0.5	2.1	0.46
	Clarithromycin	<0.20

^aT_max, time to C_max. 

^bt_1/2, terminal half-life. 

^cMIC for M. pneumoniae FH. 

^dEquivalent to T-3811.