Table 2.
Incidence of anaphylaxis due to BVA by subgroup.
| Group | Incidence (%, 95% CI) | ||
|---|---|---|---|
| Observational Studies (59,030 Participants) |
RCTs (703 Participants) |
Total (59,733 Participants) |
|
| No. of anaphylaxis | 26 | 1 | 27 |
| Overall incidence in all studies | 0.044 (0.027–0.061) | 0.142 (−0.136 to 0.421) | 0.045 (0.028–0.062) |
| Incidence by subgroup (No. studies that presented data) | |||
| Sex (37) | |||
| Men | 0.019 (−0.019 to 0.057) | 0 | 0.019 (−0.018 to 0.055) |
| Women | 0.089 (0.011–0.167) | 0 | 0.083 (0.010–0.157) |
| Main complaints (39) | |||
| G00-G99 a | 1.075 (−1.021 to 3.171) | 0 | 0.885 (−0.842 to 2.612) |
| S00-T98 b | 0 | 1.639 (−1.547 to 4.826) | 1.299 (−1.230 to 3.828) |
| M00-M99 c | 0.043 (0.026–0.060) | 0 | 0.043 (0.026–0.060) |
| Others (obesity) | 0 | 0 | 0 |
| No information d | 0 | 0 | 0 |
| Skin test (49) | |||
| Yes | 0.036 (0.007–0.065) | 0.267 (−0.255 to 0.789) | 0.041 (0.011–0.072) |
| No | |||
| No information d | 0.047 (0.026–0.068) | 0 | 0.047 (0.026–0.067) |
| Publication year (49) | |||
| –1999 | 3.226 (−2.994 to 9.446) | 0 | 1.099 (−1.043 to 3.241) |
| 2000–2009 | 0.049 (0.025–0.074) | 0 | 0.049 (0.025–0.073) |
| 2010–2021 | 0.034 (0.012–0.056) | 0.379 (−0.362 to 1.120) | 0.037 (0.014–0.060) |
a Diseases of the nervous system; b injury, poisoning, and certain other consequences of external causes; c diseases of the musculoskeletal system and connective tissue; d relevant information is not presented in the articles.