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. Author manuscript; available in PMC: 2022 Apr 22.
Published in final edited form as: Cell Rep. 2022 Mar 1;38(9):110454. doi: 10.1016/j.celrep.2022.110454

Table 1.

Gender-associated distinct patterns of the hepatic and splenic immune responses during aging

Immunological patterns Male Female
CD4+/CD8+ T cells hepatic CD4+ > CD8+
splenic CD4+ > CD8+ 		hepatic CD4+ > CD8+
splenic CD4+ > CD8+
CD4+ Th cells hepatic Th17 > Th1 > Th2
splenic Th17 > Th1 > Th2		 hepatic Th1 = Th17 = Th2
splenic Th1 = Th17 > Th2
NKT/NK cells hepatic NKT > NK
splenic NKT = NK		 hepatic NKT = NK
splenic NKT = NK
Hepatic T cells CD8+ Tcm > Tn > Te = Tem
CD4+ Tcm > Te = Tem > Tn		 CD8+ Te = Tem = Tcm = Tn
CD4+ Te = Tem > Tcm > Tn
Splenic T cells CD8+ Tcm > Tn > Te = Tem
CD4+ Tcm > Te = Tn > Tem		 CD8+ Tcm > Tn > Te = Tem
CD4+ Tcm > Te > Tn > Tem