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. Author manuscript; available in PMC: 2022 Apr 22.
Published in final edited form as: Cell Rep. 2022 Mar 1;38(9):110454. doi: 10.1016/j.celrep.2022.110454

Table 2.

Patterns of the hepatic and splenic immune responses associated with the progression or inhibition of HCC

Immunological patterns Tumor progression Partial rescue from HCC Complete rescue from HCC
CD4+/CD8+ T cells hepatic CD8+ > CD4+
splenic CD8+ > CD4+ 		hepatic CD8+ = CD4+
splenic CD8+ > CD4+ 		hepatic CD8+ > CD4+
splenic CD8+ = CD4+
CD4+ Th cells hepatic Th1 > Th17 > Th2
splenic Th1 = Th17 > Th2		 hepatic Th1 = Th17 > Th2
splenic Th1 > Th17 > Th2		 hepatic Th1 = Th17 = Th2
splenic Th1 = Th17 > Th2
NKT/NK cells hepatic NKT > NK
splenic NKT > NK		 hepatic NKT = NK
splenic NKT = NK		 hepatic NKT = NK
splenic NKT = NK
Macrophages hepatic M1 > M2
splenic M1 > M2		 hepatic M1 > M2
splenic M1 > M2		 hepatic M1 = M2
splenic M1 > M2
Hepatic T cells CD8+ and CD4+ Te > Tcm CD8+ and CD4+ Te > Tcm CD8+ and CD4+ Te > Tcm