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. 2022 Apr 15;14(4):866. doi: 10.3390/pharmaceutics14040866

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Different nanocarriers being utilized for targeting TME to overcome multi-drug resistance: (a) Nanoparticles loaded with two different drugs for co-delivery at target site for synergistic therapeutic action. (b) Theranostic nanoparticles co-loaded with both therapeutic and diagnostic agents. (c) Stimuli responsive nanoparticles respond against different components of TME such as pH change, ions change, different oxygenation. (d) Multifunctional branched polymeric dendrimer-based nanocarrier loaded with drugs. (e) Nanoparticles loaded with both drugs and nucleic acids (siRNA, miRNA) for synergistic therapeutic action (f) Liposomes loaded drugs for targeted delivery. Reproduced from Ref. [24], (2022), with permission from Elsevier.