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. 2022 Apr 15;14(4):866. doi: 10.3390/pharmaceutics14040866

Figure 7.

Figure 7

Cancer nanotherapeutics approaches to counter hypoxic conditions within tumor microenvironment, which is prime contributing factor for drug resistance. In this approach, specific drugs that can counter hypoxic environment are loaded within nanocarriers. Nanoparticulate system further specifically releases drugs in tumor microenvironment to modulate the hypoxic environment and causes cell death. Reproduces from Ref. [119], (2022), with permission from Elsevier.