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Invasion patterns of breast-to-brain metastasis. (A) Breast-to-brain metastases are of the papillary type and characterized by the abundant vessel co-option and close direct contacts between the breast cancer cells, blood vessels, and pericytes. (B) Brain metastases of the pushing type, originating, for example, from colon cancer, show a distinct collagen layer separating the metastatic lesion from the capillaries and surrounding pericytes.
