Figure 6.

A proposal for a targeted BLYM-777 consortium panel. Based on 45 studies, we propose a knowledge-based, biology-driven targeted (t)GEP consortium panel, called BLYM-777. This BLYM-777 panel primarily focuses on DLBCL and covers 777 B-cell lymphoma relevant genes, including their involved pathways (f.e., NF-κB, NOTCH, PI3K). Accordingly, genes were included for COO identification, TME-focused signatures, ecotypes, DHITsig, differentially expressed genes found in wildtype-TP53 DLBCL, and genes relevant for resistance to CAR T-cell or bispecific antibody therapy. Moreover, 95 genes important for current molecular classification based on NGS results have been included.