Table 2.
Composition and gelation properties of plain and hybrid niosomal in situ gels.
| Formulation Code | Water% | Niosomes *% (w/w) | P407% (w/w) | P188% (w/w) | Ch% (w/w) | Tsol–gel
(°C) |
Gelation Time (s) | Gel Erosion Time (h) |
|---|---|---|---|---|---|---|---|---|
| G1 | 75 | - | 25 | - | - | <22 # | - | - |
| G2 | 80 | - | 20 | - | - | <27 # | - | - |
| G3 | 72 | - | 20 | 8 | - | 33 ± 0.7 # 31 ± 0.2 ** |
10 ± 1.7 # | 4 ± 0.2 |
| G4 | 70 | - | 20 | 10 | - | 40 ± 1.1 # | 30 ± 2.1 # | - |
| G5 | 62 | - | 20 | 8 | 10 | 31 ± 0.8 # 27 ± 0.4 ** |
15 ± 1.0 # | 4.5 ± 0.1 |
| G6 | 52 | - | 20 | 8 | 20 | 30 ± 1.5 # | 30 ± 2.3 # | - |
| G7 | 10 | 62 | 20 | 8 | - | 33 ± 1.1 # 31 ± 0.8** |
10 ± 1.4 #35 ± 1.1 ** | 4 ± 0.2 |
| G8 | - | 62 | 20 | 8 | 10 | 30 ± 1.3 # 27 ± 0.3 ** |
15 ± 1.1 #33 ± 1.0 ** | 4.5 ± 0.1 |
* Formulation S8; # Visually observed; ** Values obtained by dynamic rheological measurements.