Table 4.

Linear regression analysis on trough enalaprilat concentration.

	Coefficient	SE	p-Value
Intercept	0.384	0.303	0.20680
Age	0.023	0.004	1.17 × 10−8	***
Single dose, ln	0.556	0.069	2.34 × 10−14	***
CES1 rs2244613_AC	−0.12	0.087	0.16724
CES1 rs2244613_CC	−0.49	0.161	0.00263	**
wt/CES1A1c	−0.111	0.088	0.20873
CES1A1c/CES1A1c	−0.605	0.294	0.04088	*
Adjusted R-squared: 0.2957, p-value: <2.2 × 10−16

ln—natural logarithm, SE—standard error. For genetic predictors, wild-type homozygotes were the reference. Significance codes (p-value): “***”—<0.001, “**”—<0.01, “*”—<0.05.