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Relation of N/P with peptide concentration and amount of ionizable nitrogen in the peptide conjugates.
| Peptide | N/P | siRNA (µM) |
Peptide Conc. (µM) | W/W Ratio (Peptide/siRNA) | Molar Ratio (Peptide/siRNA) |
|---|---|---|---|---|---|
| Oleyl-(HR)4 | 40 | 1 | 43.6 | 52.5 | 480 |
| Oleyl-R1-(HR)4 | 40 | 1 | 34.9 | 46.5 | 384 |
| Oleyl-R2-(HR)4 | 40 | 1 | 29.1 | 42.5 | 320 |
| Oleyl-R3-(HR)4 | 40 | 1 | 24.9 | 39.7 | 274 |
| Oleyl-R4-(HR)4 | 40 | 1 | 21.8 | 37.5 | 240 |
| Oleyl-R5-(HR)4 | 40 | 1 | 19.4 | 35.9 | 213 |
