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. 2022 Mar 30;14(4):752. doi: 10.3390/pharmaceutics14040752

Figure 5.

Figure 5

Confocal fluorescence microscopy analysis of skin samples resultant from the permeation assay. Skin treated for 24 h with (A) calcein solution; (B) calcein-alginate hydrogel; (C) calcein-alginate/k-CRG hydrogel; (D) 800 calcein-alginate/k-CRG MN for 10 min; (E) 400 calcein-alginate MN; (F) 800 calcein-alginate MN; (G) 400 calcein-alginate/k-CRG MN; (H) 800 calceinalginate/k-CRG MN. The # symbol represents the orientation of the epidermis. The red arrow indicates the structures possibly created by the MNs. Scale bar 200 µm.