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. 2022 Mar 31;12(4):309. doi: 10.3390/metabo12040309

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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KEGG global metabolic network of key metabolites. (a) Metabolite-metabolite interaction network analysis of target metabolites. Known metabolites are presented as red nodes and unknown metabolites are presented as blue nodes. Correlations of metabolites are denoted as edges. NADP = nicotinamide adenine dinucleotide phosphate; NADH = nicotinamide adenine dinucleotide. (b) Gene-metabolite interaction network analysis of the target metabolites. Known metabolites are presented as pink nodes and key genes are presented as green nodes. Correlations are denoted as edges.