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. 2022 Apr 15;23(8):4386. doi: 10.3390/ijms23084386

Figure 2.

Figure 2

Simplified model of the regulatory network connecting L-arginine metabolism, c-di-GMP signaling and biofilm formation in P. putida KT2440. In the presence of arginine, ArgR positively controls arginine transport and negatively controls de novo arginine biosynthesis; intracellular arginine indirectly influences the c-di-GMP levels (and, therefore, biofilm formation) and, in turn, c-di-GMP modulates the expression of argR, thus establishing a feedback loop [63].