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. 2022 Feb 25;30(Suppl 1):425–440. doi: 10.3233/THC-THC228039

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© 2022 – The authors. Published by IOS Press.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — $\beta$ -catenin binds to the promotor region of YAP. (A) The relation of YAP and the promoter region $\beta$ -catenin detected by CHIP assay. (B) The relation of YAP and the promoter region TCF4 detected by CHIP assay. (C) Luciferase reporter activity of BGC-823 cells transfected with psicheck-2 (Control), psicheck-2-yap-wt (WT), psicheck-2- yap-mut1 (TCF4), psicheck-2-yap-mut2 ( $\beta$ -catenin). (D) Luciferase reporter activity of BGC-823 cells transfected with pcDNA3.1/EGFP/IRES- $\beta$ -catenin $+$ psicheck-2-yap-wt, pcDNA3.1/EGFP/IRES- $\beta$ -catenin $+$ psicheck-2 – yap-mut ( $\beta$ -catenin). ${}^{*}P<$ 0.05, ${}^{**}P<$ 0.01, ${}^{***}P<$ 0.001.