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. 2022 Mar 25;12(4):438. doi: 10.3390/brainsci12040438

Figure 3.

Figure 3

Overview of four networks relevant in major depressive disorder (MD), according to [53], and obsessive–compulsive disorder (OCD), extended by one overarching system for homeostasis, the MAINTENANCE system. Subcortical extensions according to [19]. A DBS electrode is positioned in the slMFB as part of the greater MFB system. Colored lines represent fiber connections; spheres represent network hubs. Capitalization of SEEKING and PANIC refers to affective neuroscience nomenclature [27] and to subcortical networks [19] which show affect-driven behavior upon stimulation. In analogy, the homeostasis network is termed MAINTENANCE since it reacts to direct stimulation (DBS) in a clinical setting. (Legend: AMY, amygdala; CB, cerebellum; CIB, cingulate bundle; DBS, Deep Brain Stimulation (lead); MDT, mediodorsal thalamus; NAC, nucleus accumbens; STN, subthalamic nucleus; VTA, ventral tegmental area; BA, Brodmann’s areas [54]; dlPFC, dorsolateral prefrontal cortex; OFC, orbitofrontal cortex; lOFC, lateral OFC; PFC, prefrontal cortex; PMC, premotor cortex; PAG, periaqueductal gray).