Table 4.
Hazard ratios (HRs) and 95% confidence intervals (Cis) for the cardiovascular disease incidence and mortalities according to the combination of metabolic health risks and obesity status in KoGES.
| Total (n) |
Events (n) |
Follow-Up (Person-Years) | Incidence Rate (per 1000 Person-Years) |
HR (95% CI) | |
|---|---|---|---|---|---|
| Cardiovascular disease incidence | |||||
| MHN | 2937 | 183 | 30,729 | 5.96 | 1.00 (ref) |
| MUN | 1356 | 172 | 13,390 | 12.85 | 1.69 (1.36–2.09) |
| MHO | 1579 | 118 | 16,512 | 7.15 | 1.36 (1.07–1.73) |
| MUO | 1658 | 224 | 16,710 | 13.41 | 1.94 (1.59–2.38) |
| Cardiovascular mortality | |||||
| MHN | 2937 | 31 | 51,329 | 0.6 | 1.00 (ref) |
| MUN | 1356 | 38 | 23,303 | 1.63 | 1.64 (0.99–2.70) |
| MHO | 1579 | 11 | 27,814 | 0.4 | 1.01 (0.50–2.03) |
| MUO | 1658 | 39 | 28,791 | 1.35 | 2.01 (1.23–3.29) |
| Cancer incidence | |||||
| MHN | 2937 | 134 | 31,000 | 4.32 | 1.00 (ref) |
| MUN | 1356 | 59 | 13,965 | 4.22 | 0.94 (0.69–1.29) |
| MHO | 1579 | 63 | 16,867 | 3.74 | 0.88 (0.65–1.20) |
| MUO | 1658 | 86 | 17,585 | 4.89 | 1.00 (0.75–1.33) |
| Cancer mortality | |||||
| MHN | 2937 | 81 | 51,329 | 1.58 | 1.00 (ref) |
| MUN | 1356 | 50 | 23,303 | 2.15 | 1.03 (0.71–1.49) |
| MHO | 1579 | 28 | 27,814 | 1.01 | 0.77 (0.49–1.21) |
| MUO | 1658 | 51 | 28,791 | 1.77 | 1.02 (0.71–1.48) |
| All-cause mortality | |||||
| MHN | 2937 | 185 | 51,329 | 3.6 | 1.00 (ref) |
| MUN | 1356 | 170 | 23,303 | 7.3 | 1.41 (1.13–1.75) |
| MHO | 1579 | 63 | 27,814 | 2.27 | 0.83 (0.62–1.12) |
| MUO | 1658 | 149 | 28,791 | 5.18 | 1.30 (1.04–1.62) |
The HRs (95% CI) were calculated using a Cox proportional hazard regression model adjusting for age, sex, residence area, education level, household income, smoking status, drinking status, and the metabolic equivalent of the task. BMI: body mass index; KoGES: Korean Genome and Epidemiology Study; MHN: metabolically healthy non-obese (BMI < 25 kg/m2 & 0 metabolic health risk); MHO: metabolically healthy and obese (BMI ≥ 25 kg/m2 & 0 metabolic health risk); MUN: metabolically unhealthy non-obese (BMI < 25 kg/m2 & 1–3 metabolic health risks); MUO: metabolically unhealthy obese (BMI ≥ 25 kg/m2 & 1–3 metabolic health risks); n: Number.