Table 3.

Motor changes over disease progression in three HD mouse models

Mouse model	N171-82Q				zQ175			BACHD
Disease stage	Early	Mid	Late	Late	Early	Mid	Late	Early	Mid	Late
Age (Unit)	6	10	14	18	6	8.5	18	2	6	12
	Weeks				Months			Months
Weight	=	=	↓↓↓↓	↓↓↓↓	↓	↓↓	↓↓↓↓	↑↑ ↑↑	↑↑ ↑↑	↑↑ ↑↑
Rotarod Performance	↓↓	↓↓	↓↓	↓↓↓↓	=	↓	↓	↓↓↓↓	↓↓↓↓	↓↓↓
Rotarod Learning	=	=	↓↓↓↓	=	=	=	=	↓↓	↓↓↓↓	↓↓
FGS	↓↓↓	↓↓↓↓	↓↓↓↓	↓↓↓↓	↓↓↓	NA	NA	↓*	↓↓↓↓*	↓↓↓*
DR – T-turn	=	↓	=	NC	=	NA	NA	↓↓	=	↓↓ ↓↓
DR – T-total	↓	↓↓	=	NC	↑↑	NA	NA	↓↓ ↓↓	↓↓ ↓	↓↓ ↓↓
DR – Latency	↓↓ ↓	=	↓	NC	↑	NA	NA	↓↓	=	=
NB – Cross time	↓↓	NA	NA	NA	NA	NA	NA	↓↓ ↓	↓↓ ↓	↓↓ ↓↓
NB – Slips	=	NA	NA	NA	NA	NA	NA	↑↑↑	↑↑	↑↑↑
NB – Latency	↑↑↑	NA	NA	NA	NA	NA	NA	=	=	=
CT – Frequency	NA	NA	NA	NA	NA	NA	NA	↓↓↓	↓↓↓	↓↓
AC – Distance	=	=	=	=	=	=	↓↓↓↓	↓↓	=	↓↓↓↓
AC – Jump	=	=	=	↓↓	=	=	=	↓↓↓↓*	↓↓↓↓*	↓↓↓↓
AC – Rearing	↓	=	=	↓	=	=	↓↓	=	=	↓↓↓↓
Recommended	Rotarod	Rotarod	Weight	Weight	Weight	Weight	Weight	Weight	Weight	Weight
	FGS	FGS	Rotarod	Rotarod	FGS	Rotarod	Rotarod	Rotarod	Rotarod	Rotarod
	DR	DR	FGS	FGS	DR		AC	FGS	FGS	FGS
	NB		DR	AC				DR	DR	DR
	AC							NB	NB	NB
								CT	CT	CT
								AC	AC	AC

Black arrows represent expected behavior direction while red arrows indicate behavior that are not following the human HD pathology. Italicized recommended tests indicate unexpected result direction. *Weight-corrected results; AC, Activity chamber; CT, Climbing test; DR, Descending rod; FGS, Forelimb grip strength; NA, Not available; NB, Narrow beam; NC, Mice were not capable to perform the task; T-time, Time to descend the descending rod; T-turn, Time to turn downward on the descending rod.