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. 2022 Apr 8;13:852330. doi: 10.3389/fneur.2022.852330

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Copyright © 2022 Zheng, Yingli, Shengli, Zhifeng, Bo, Gangqiang and Yingwei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anterior CC microstructural integrity has an indirect influence on depression severity in MDD patients. Disruption of anterior CC microstructural integrity has an indirect impact (through exerting effects on FC of the bilateral medial prefrontal cortex) on depression severity in MDD patients.