Table 1.

Inclusion and exclusion criteria.

Inclusion criteria
1. ≥18 years old 2. Positive results for COVID-19 with cough and respiratory involvement 3. Oxygen saturation ≥92% without the need for mechanical ventilation or severe respiratory insufficiency that will require immediate intubation 4. Agrees to use the nVNS device according to the instructions and will follow the requirements of the study 5. Able to provide written informed consent
Exclusion criteria
1. Pregnant 2. Requires home oxygen therapy at the start of the study and before the development of COVID-19 3. Already enrolled in a clinical trial for COVID-19 4. History of aneurysm, intracranial hemorrhage, brain tumor, or significant head trauma 5. Known or suspected severe atherosclerotic cardiovascular disease, severe carotid artery disease, congestive heart failure, known severe coronary artery disease, or recent myocardial infarction 6. Uncontrolled high blood pressure 7. Presence of an implanted electrical and/or neurostimulator device, metal cervical spine material, or a metal implant near the site of nVNS 8. Is from a vulnerable population or has a condition that affects their ability to provide informed consent or comply with follow-up requirements or has compromised their ability to provide self-assessment

COVID-19, coronavirus disease 2019; nVNS, non-invasive vagus nerve stimulation.