Table 2.
Summary of study assessments.
| Assessed every study day | Assessed on days 1, 3, 5, and/or final study daya |
|---|---|
| No. of nVNS doses administered | PaO2/FiO2 |
| Dyspnea (yes/no) | Cytokines (TNF-α, IL-6, IL-1β) |
| Oxygen saturation | Procalcitonin |
| ICU admission (yes/no) | CRP |
| Need for ventilation (yes/no) | D-dimer |
| Survival (yes/no) | CBC (absolute lymphocytes, white blood cell count) |
| Discharged (yes/no) | Coagulation |
| Blood pressure | SAA |
| Adverse events | Ferritin |
| Haptoglobin |
a
The final study day was the day of discharge from the hospital, referral to the ICU, start of mechanical ventilation, or study withdrawal for each participant.
CBC, complete blood count; CRP, C-reactive protein; FiO2, fraction of inspired oxygen; IL, interleukin; ICU, intensive care unit; nVNS, non-invasive vagus nerve stimulation; PaO2, partial pressure of oxygen; SAA, serum amyloid A; SaO2, oxygen saturation; TNF, tumor necrosis factor.