Table 2.
MRI volume corrected for Multiple Comparisons in MMC subjects: p values after correcting ICV linearly and FDR. All subjects are right-handed.
| Anatomical Region | ≤30 Years Mean SD |
≥31 Years Mean SD |
p Value Corrected FDR |
|---|---|---|---|
| VOLUME DATA | |||
| WHITE MATTER | 455,195 ± 40,045 | 447,456 ± 38,578 | 0.9285 |
| GRAY MATTER | 754,913 ± 46,840 | 715,865 ± 59,604 | <0.0001 |
| CSF | 244,804 ± 26,320 | 270,899 ± 33,336 | 0.000851 |
| LEFT CEREBELLUM WM | 13,223 ± 1465 | 12,083 ± 1139 | 0.0715 |
| RIGHT CEREBELLUM WM | 13,101 ± 1408 | 11,762 ± 921 | 0.014468 |
| LEFT CEREBELLUM CORTEX | 48,482 ± 4679 | 42,265 ± 3688 | 0.000114 |
| RIGHT CEREBELLUM CORTEX | 49,084 ± 4538 | 42,353 ± 3409 | <0.0001 |
| LEFT CAUDATE | 3529 ± 378 | 3216 ± 319 | 0.0153 |
| RIGHT CAUDATE | 3682 ± 382 | 3320 ± 328 | 0.006498 |
| LEFT PUTAMEN | 5115 ± 639 | 4610 ± 656 | 0.0993 |
| RIGHT PUTAMEN | 5004 ± 731 | 4561 ± 682 | 0.1785 |
| LEFT PALLIDUM | 1829 ± 368 | 1716 ± 222 | 0.6175 |
| RIGHT PALLIDUM | 1753 ± 323 | 1654 ± 269 | 0.5656 |
| LEFT HIPPOCAMPUS | 3986 ± 321 | 4011 ± 346 | 0.5777 |
| RIGHT HIPPOCAMPUS | 4162 ± 434 | 4166 ± 388 | 0.4395 |
| LEFT AMYGDALA | 1503 ± 163 | 1472 ± 155 | 0.8599 |
| RIGHT AMYGDALA | 1600 ± 190 | 1559 ± 168 | 0.8045 |
| LEFT ACCUMBENS AREA | 634 ± 105 | 555 ± 115 | 0.0377 |
| RIGHT ACCUMBENS AREA | 583 ± 99 | 517 ± 83 | 0.0758 |
| OPTIC CHIASM | 231 ± 33 | 256 ± 24 | 0.007 |
| CORPUS CALLOSUM POST | 982 ± 176 | 939 ± 126 | 0.6781 |
| CORPUS CALLOSUM MIDPOSTERIOR | 534 ± 110 | 468 ± 76 | 0.1625 |
| CORPUS CALLOSUM CENTRAL | 511 ± 103 | 441 ± 67 | 0.0981 |
| SURFACE AREA DATA | |||
| LEFT GYRUS FRONTAL INF OPERCULAR | 3269 ± 491 | 2777 ± 426 | 0.013 |
| RIGHT GYRUS FRONTAL INF OPERCULAR | 3261 ± 475 | 2813 ± 490 | 0.0289 |
| LEFT GYRUS FRONTAL INF ORBITAL | 1193 ± 168 | 1057 ± 155 | 0.0385 |
| LEFT GYRUS FRONTAL MIDDLE | 9961 ± 931 | 8659 ± 1110 | 0.004605 |
| LEFT GYRUS OCC TEMP MEDIAL LINGUAL | 4653 ± 591 | 4095 ± 621 | 0.0397 |
| LEFT GYRUS ORBITAL | 5985 ± 702 | 5451 ± 787 | 0.0440 |
| LEFT PARIETAL INF ANGULAR | 5627 ± 970 | 4912 ± 871 | 0.0313 |
| LEFT GYRUS TEMPORAL INFERIOR | 7085 ± 1306 | 6307 ± 1085 | 0.0352 |
| LEFT GYRUS TEMPORAL MIDDLE | 7214 ± 757 | 6411 ± 627 | 0.000855 |
| LEFT LAT FIS ANTERIOR HORIZONTAL | 424 ± 86 | 323 ± 93 | 0.0082 |
| LEFT LAT FIS ANTERIOR VERTICAL | 480 ± 84 | 379 ± 85 | 0.002906 |
| LEFT SULCUS ORBITAL LATERAL | 513 ± 122 | 397 ± 104 | 0.005822 |
| LEFT SULCUS ORBITAL H SHAPED | 2453 ± 335 | 2149 ± 374 | 0.013217 |
| RIGHT GYRI & SULCUS OCCIPITAL INFERIOR | 2494 ± 364 | 2147 ± 500 | 0.0425 |
| RIGHT GYRI & SULCUS CINGULATE ANTERIOR | 5211 ± 456 | 4706 ± 749 | 0.015274 |
| RIGHT G CUNNEUS | 2984 ± 405 | 2692 ± 281 | 0.0675 |
| RIGHT G FRONTAL INF OPERCULAR | 3261 ± 475 | 2813 ± 490 | 0.0289 |
| RIGHT G OCCIPITAL TEMP LAT FUSIFORM | 4761 ± 592 | 4208 ± 661 | 0.014617 |
| RIGHT G PRECENTRAL | 6477 ± 794 | 5707 ± 995 | 0.0316 |
| RIGHT G TEMP SUP GT TRANSVERSE | 778 ± 115 | 677 ± 105 | 0.0349 |
| RIGHT G TEMP SUPERIOR LATERAL | 4754 ± 527 | 4329 ± 459 | 0.0320 |
| RIGHT G TEMPORAL INFERIOR | 6768 ± 1074 | 5917 ± 964 | 0.0255 |
| RIGHT G TEMPORAL MIDDLE | 8176 ± 892 | 7175 ± 864 | 0.00021 |
| RIGHT LAT ANT FIS HORIZONTAL | 531 ± 173 | 425 ± 114 | 0.0488 |
| RIGHT SULCUS OCCIP MIDDLE LUNATUS | 1191 ± 288 | 999 ± 175 | 0.0588 |
| RIGHT SULCUS orbital MED OLFACTORY | 972 ± 125 | 899 ± 111 | 0.0291 |
| RIGHT SULCUS H SHAPED | 2375 ± 339 | 2099 ± 249 | 0.013 |
| RIGHT SULCUS TEMPORAL SUPERIOR | 8880 ± 1142 | 8038 ± 898 | 0.0498 |
| LEFT G PARIETAL ING ANGULAR | 5628 ± 971 | 4913 ± 871 | 0.0313 |
| LEFT G TEMPORAL MIDDLE | 7215 ± 758 | 6412 ± 628 | 0.0009 |
| CORTICAL THICKNESS DATA | |||
| LEFT G&S SUBCENTRAL | 2.69 ± 0.17 | 2.55 ± 0.14 | 0.02358 |
| LEFT G&S TRANV FRONTAL POL | 2.71 ± 0.17 | 2.55 ± 0.13 | 0.00318 |
| LEFT G&S CINGULAR ANTERIOR | 2.66 ± 0.15 | 2.49 ± 0.15 | 0.004167 |
| LEFT G&S CINGULATE MID ANTERIOR | 2.68 ± 0.19 | 2.47 ± 0.19 | 0.008505 |
| LEFT G&S CINGULATE MID POSTERIOR | 2.57 ± 0.17 | 2.33 ± 0.33 | <0.0001 |
| LEFT FRONTAL INF OPERCULAR | 2.77 ± 0.15 | 2.61 ± 0.15 | 0.008622 |
| LEFT G FRONTAL INF TRIANGULAR | 2.69 ± 0.17 | 2.54 ± 0.14 | 0.00665 |
| LEFT FRONTAL MIDDLE | 2.64 ± 0.14 | 2.53 ± 0.09 | 0.01592 |
| LEFT G FRONTAL SUPERIOR | 2.98 ± 0.14 | 2.81 ± 0.12 | 0.00036 |
| LEFT G OCCIPITAL TEMP LAT FUSIFORM | 2.91 ± 0.15 | 2.81 ± 0.14 | 0.01941 |
| LEFT G OCC TEMP MEDIAL LINGUAL | 2.06 ± 0.07 | 1.95 ± 0.08 | 0.00075 |
| LEFT G PRECUNNEUS | 2.43 ± 0.12 | 2.32 ± 0.17 | 0.0292 |
| LEFT LAT FIS ANTERIOR HORIZONTAL | 2.34 ± 0.28 | 2.09 ± 0.22 | 0.0257 |
| LEFT LAT FIS ANTERIOR VERTICAL | 2.30 ± 0.34 | 2.02 ± 0.21 | 0.01803 |
| LEFT S CALCARINE | 1.89 ± 0.12 | 1.80 ± 0.095 | 0.0544 |
| LEFT S CINGULAR INSULA SUPERIOR | 2.57 ± 0.12 | 2.43 ± 0.14 | 0.00451 |
| LEFT S FRONTAL SUPERIOR | 2.44 ± 0.16 | 2.32 ± 0.13 | 0.0068 |
| LEFT S PRECENTRAL SUPERIOR PAR | 2.42 ± 0.11 | 2.28 ± 0.21 | 0.01671 |
| LEFT G&S CINGULATE ANTERIOR | 2.58 ± 0.17 | 2.43 ± 0.10 | 0.0097 |
| LEFT G&S CINGULATE MID ANTERIOR | 2.66 ± 0.14 | 2.50 ± 0.13 | 0.0053 |
| LEFT G&S CINGULATE MID POSTERIOR | 2.58 ± 0.12 | 2.43 ± 0.13 | 0.0020 |
| LEFT G CINGULATE POSTCENTRAL | 2.87 ± 0.24 | 2.68 ± 0.15 | 0.01919 |
| LEFT G CUNNEUS | 1.85 ± 0.11 | 1.75 ± 0.07 | 0.01230 |
| LEFT G FRONTAL INF OPERCULAR | 2.78 ± 0.18 | 2.59 ± 0.21 | 0.0245 |
| LEFT G FRONTAL INF TRIANGULAR | 2.76 ± 0.17 | 2.60 ± 0.18 | 0.0147 |
| LEFT G FRONTAL MIDDLE | 2.65 ± 0.11 | 2.55 ± 0.11 | 0.0172 |
| LEFT G FRONTAL SUPERIOR | 2.95 ± 0.14 | 2.79 ± 0.1 | 0.0016 |
| LEFT OCCIPITAL MIDDLE | 2.63 ± 0.12 | 2.55 ± 0.08 | 0.0319 |
| LEFT SUP TEMP LATERAL FUSIFORM | 2.99 ± 0.14 | 2.86 ± 0.16 | 0.0137 |
| LEFT G PARIETAL INF SUPRAMARGINAL | 2.73 ± 0.11 | 2.64 ± 0.13 | 0.0386 |
| LEFT G PRECENTRAL | 2.96 ± 0.14 | 2.78 ± 0.28 | 0.0103 |
| LEFT G CUNNEUS | 2.43 ± 0.13 | 2.34 ± 0.15 | 0.0676 |
| LEFT CIRCULAR INSULAR SUPERIOR | 2.61 ± 0.10 | 2.47 ± 0.16 | 0.011 |
| LEFT S FRONTAL SUPERIOR | 2.42 ± 0.16 | 2.28 ± 0.14 | 0.016 |
| LEFT S PRECENTRAL SUPERIOR | 2.44 ± 0.17 | 2.30 ± 0.22 | 0.026 |