Table 1.
Summary of main manuscripts focused on the role of 18F-FDG PET/CT for the imaging of advanced MM.
| Authors | Year | Type of Study | Setting | Number of Patients |
Comment |
|---|---|---|---|---|---|
| Gulec et al. [18] | 2003 | Retrospective, single-center | Impact on clinical management | n = 59 | 18F-FDG PET/CT detected additional lesions with respect to conventional imaging (total body CT) in the majority of patients and significantly impacted on therapeutic decision. |
| Querellou et al. [19] | 2010 | Retrospective, single-center | Additional value of lower limbs scan in MM patients |
n = 122 | In patients without known or suspected MM focuses on the lower limbs, additional scan did not add significant information or impacted on clinical managment. |
| Pfluger et al. [20] | 2011 | Retrospective, Single-center |
Contribution of contrast-enhanced CT (ceCT) for PET/CT MM imaging | n = 50 | PET/CT and PET/ceCT equally performed in advanced MM, especially in terms of specificity, therefore the use of conventional PET/CT (no-contrast media) modality is justified. |
| Bastiaannet et al. [21] | 2012 | Prospective, Single-center |
Prognostic impact of PET-derived parameter, SUVmax | n = 80 | In MM at stage IIIB, SUVmax measured on metastatic nodes before surgery can be used to patients prognostic stratification. |
| Holtkamp et al. [22] | 2020 | Prospective, Single-center |
Staging and follow-up in patients with in-transit or satellite MM metastases | n = 25 | PET/CT upstaged 4 out of 25 patients (16%) therefore leading to a change in clinical management. Furthermore, PET/CT detected the onset of distant metastases during follow-up in 10 cases within 6 months from diagnosis. |
| Klingestein et al. [23] | 2010 | Retrospective, Single-center |
Restaging and follow-up of uveal melanoma | n = 11 | PET/CT correctly identified metastases to liver, lungs, nodes and adrenal glands. |
| Cohen et al. [24] | 2018 | Retrospective, Single-center |
Staging uveal melanoma | n = 108 | PET/CT combined with abdominal ultrasonography resulted positive for metastases in 3 cases of uveal melanoma and identified a second primary malignancy in the 9% of the examined subjects. |