. 2022 Mar 29;14(4):740. doi: 10.3390/pharmaceutics14040740

Table 2.

Biological activity towards ferrous ion-chelating and hyaluronidase inhibition of S. baicalensis radix lyophilized extract, chitosans, and the binary systems.

Extract or Chitosan System	IC₅₀ (mg mL⁻¹)
Extract or Chitosan System	Metal Chelating Activity	Hyaluronidase Inhibition
SBE	8.54 ± 0.13 ^d	2.00 ± 0.06 ^d
SBE/Cs 80:500 2:1	3.27 ± 0.03 ^c	0.19 ± 0.00 ^c
SBE/Cs 80:1000 2:1	3.11 ± 0.05 ^b	0.21 ± 0.00 ^c
SBE/Cs 80:500 1:1	3.01 ± 0.12 ^a	0.14 ± 0.00 ^b
SBE/Cs 80:1000 1:1	3.06 ± 0.17 ^a,b	0.15 ± 0.00 ^b
SBE/Cs 80:500 1:2	2.97 ± 0.03 ^a	0.15 ± 0.00 ^b
SBE/Cs 80:1000 1:2	3.14 ± 0.03 ^b	0.14 ± 0.00 ^b
Cs 80:500	n.o.	0.03 ± 0.00 ^a
Cs 80:1000	n.o.	0.03 ± 0.00 ^a

The results are presented as the mean ± SD (n = 6). Mean values with the same letter are not significantly different at p < 0.05 using Duncan’s multiple range test. “a” of the alphabet stands for the lowest values (the higher activity), “b–d” stand for the statistically significant increasing values. n.o.—not observed at the concentration of 1–10 mg mL⁻¹.