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Hypusine Pathway. Spermidine is used as a substrate to form deoxyhypusine by the rate-limiting enzyme deoxyhypusine synthase (DHPS), which then transfers deoxyhypusine to eIF5A. Deoxyhypusine is then converted to hypusine by deoxyhypusine hydroxylase (DOHH), resulting in hypusinated eIF5A.
