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. 2022 Apr 5;11(4):713. doi: 10.3390/antiox11040713

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Analysis of specific mTOR/PI3K-AKT/MEK-ERK pathway with RNA-seq. Heat map of 3 enriched genes (PTK2, TSC2, RICTOR) involved in GTPase regulation pathway in hiPSC-RPE Control, AMDa and AMDe cells in basal condition and after 3 and 24 h POS exposure (A). Volcano plot of differentially expressed genes between hiPSC-RPE Control and AMDa cells and between hiPSC-RPE Control and AMDe cells after 3 and 24 h POS exposure (B). hiPSC-RPE Control cells N = 6, hiPSC-RPE AMDa cells N = 6, hiPSC-RPE AMDe N = 3.