Table 4.

Key mutations in the Alpha VOC.

Mutation	Type	Level	Protein Coding Gene Annotation	Codon Change	Consequence for the AA Sequence	Corresponding Protein Annotation of UCSC SARS-CoV-2
C3267T	SNV	moderate	ORF1ab	aCt3002aTt	T1001I	nsp3
C5388A	SNV	moderate	ORF1ab	gCt5123gAt	A1708D	nsp3
T6954C	SNV	moderate	ORF1ab	aTa6689aCa	I2230T	nsp3
TCTGGTTTT11288-	deletion	moderate	ORF1ab	TCTGGTTTT 11023:11031-	SGF3675:3677-	nsp6
C14408T	SNV	moderate	ORF1ab	cCt14144cTt	P4715L	nsp12
TACATG21765-	deletion	moderate	S	aTACATGtc 203:208atc	IHV68:70I	S
TTA21991-	deletion	moderate	S	gtTTAt 429-431gtt	VY143:144V	S
A23063T	SNV	moderate	S	Aat1501Tat	N501Y	S
C23271A	SNV	moderate	S	gCt1709gAt	A570D	S
A23403G	SNV	moderate	S	gAt1841gGt	D614G	S
C23604A	SNV	moderate	S	cCt2042cAt	P681H	S
C23709T	SNV	moderate	S	aCa2147aTa	T716I	S
T24506G	SNV	moderate	S	Tca2944Gca	S982A	S
G24914C	SNV	moderate	S	Gac3352Cac	D1118H	S
C27972T	SNV	high	ORF8	Caa79Taa	Q27stop	ORF8
G28048T	SNV	moderate	ORF8	aGa155aTa	R52I	ORF8
A28111G	SNV	moderate	ORF8	tAc218tGc	Y73C	ORF8
G28280C	SNV	moderate	N	Gat7Cat	D3H	N
A28281T	SNV	moderate	N	gAt8gTt	D3V	N
T28282A	SNV	moderate	N	gaT9gaA	D3E	N
G28881A	SNV	moderate	N	aGg608aAg	R203K	N
G28883C	SNV	moderate	N	Gga610Cga	G204R	N
C28977T	SNV	moderate	N	tCt704tTt	S235F	N

AA, amino acid; SNV, single nucleotide variation; ORF, open reading frame; nsp, non-structural protein; S, spike; N, nucleocapsid.