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. 2021 Dec 8;1(3):100067. doi: 10.1016/j.xgen.2021.100067

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© 2021 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Metaplastic carcinomas of breast group away from other breast carcinomas into other subtypes dictated by their predominant type of metaplasia

(A) Tabular representation of TCGA-BRCA samples according to the pan-cancer cluster of cluster assignment (CoCA) groups and histologic types. Colored rows represent breast samples clustering out of the predominant breast CoCA group.

(B) Representative disease correlation using top upregulated genes obtained after differentially expressed (DE) gene analysis between META-squamous group versus META (right panel) and META-sarcoma group versus META (left panel). PAAD, TCGA pancreatic adenocarcinoma; SARC, TCGA sarcomas; Pan-Squam, TCGA pan-squamous group; LAML, TCGA acute myeloid leukemia; BRCA, TCGA breast cancer; multiple, no specific TCGA cancer study; B&H, Benjamini-Hochberg adjusted; FDR, false discovery rate.