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. 2001 Jan;45(1):345–348. doi: 10.1128/AAC.45.1.345-348.2001

TABLE 1.

Comparative in vitro activities of ABT-773 against 362 strains of anaerobic bacteria

Organism (no. tested) Antimicrobial agent MIC (μg/ml)
Range 50% 90%a
Actinomyces spp. (8)b ABT-773 ≤0.06–≤0.06 ≤0.06
Telithromycin ≤0.06–≤0.06 ≤0.06
Clarithromycin ≤0.06–0.125 ≤0.06
Azithromycin ≤0.06–0.5 0.125
Erythromycin ≤0.06–0.25 0.125
Roxithromycin ≤0.06–0.25 0.25
Clindamycin ≤0.06–0.25 ≤0.06
Penicillin G ≤0.06–0.5 0.125
Ampicillin-sulbactam ≤0.06–0.5 ≤0.06
Levofloxacin 0.25–4 4
Metronidazole 0.25–>32 2
Eubacterium spp. (18)c ABT-773 ≤0.06–>32 ≤0.06 >32
Telithromycin ≤0.06–>32 ≤0.06 >32
Clarithromycin ≤0.06–>32 0.5 >32
Azithromycin ≤0.06–>32 4 >32
Erythromycin ≤0.06–>32 4 >32
Roxithromycin ≤0.06–>32 8 >32
Clindamycin ≤0.06–4 0.25 4
Penicillin G ≤0.06–2 0.5 2
Ampicillin-sulbactam ≤0.06–2 ≤0.06 1
Levofloxacin 0.5–4 0.5 4
Metronidazole ≤0.06–4 1 2
Lactobacillus spp. (22)d ABT-773 ≤0.06–>32 ≤0.06 >32
Telithromycin ≤0.06–>32 ≤0.06 >32
Clarithromycin ≤0.06–>32 0.5 >32
Azithromycin ≤0.06–>32 2 >32
Erythromycin ≤0.06–>32 1 >32
Roxithromycin ≤0.06–>32 2 >32
Clindamycin ≤0.06–>32 0.5 8
Penicillin G ≤0.06–1 0.125 0.5
Ampicillin-sulbactam ≤0.06–0.125 ≤0.06 ≤0.06
Levofloxacin 0.125–8 2 4
Metronidazole 0.25–>32 2 32
Propionibacterium spp. (16)e ABT-773 ≤0.06–0.125 ≤0.06 ≤0.06
Telithromycin ≤0.06–0.25 ≤0.06 ≤0.06
Clarithromycin ≤0.06–0.5 ≤0.06 ≤0.06
Azithromycin ≤0.06–16 0.125 2
Erythromycin ≤0.06–1 ≤0.06 0.5
Roxithromycin ≤0.06–2 ≤0.06 0.125
Clindamycin ≤0.06–0.5 ≤0.06 0.25
Penicillin G ≤0.06–1 ≤0.06 1
Ampicillin-sulbactam ≤0.06–0.5 0.25 1
Levofloxacin 0.125–0.5 0.25 0.5
Metronidazole 0.5–>32 0.5 >32
C. difficile (14) ABT-773 ≤0.06–>32 0.125 >32
Telithromycin ≤0.06–>32 0.125 >32
Clarithromycin 0.125–>32 0.5 >32
Azithromycin 0.5–>32 2 >32
Erythromycin 0.125–>32 1 >32
Roxithromycin 0.25–>32 2 >32
Clindamycin 0.125–>32 2 >32
Penicillin G 0.5–4 2 4
Ampicillin-sulbactam 0.125–>32 1 2
Levofloxacin 4–>32 4 >32
Metronidazole 0.25–>32 0.25 0.5
C. innocuum (11) ABT-773 ≤0.06–>32 4 >32
Telithromycin ≤0.06–>32 0.5 >32
Clarithromycin 0.25–>32 >32 >32
Azithromycin 0.25–>32 >32 >32
Erythromycin 0.5–>32 >32 >32
Roxithromycin 0.5–>32 >32 >32
Clindamycin 0.25–>32 0.5 1
Penicillin G 0.25–0.5 0.25 0.5
Ampicillin-sulbactam 0.125–0.25 0.125 0.25
Levofloxacin 2–8 4 4
Metronidazole 0.25–2 1 2
C. perfringens (16) ABT-773 ≤0.06–≤0.06 ≤0.06 ≤0.06
Telithromycin ≤0.06–0.25 0.25 0.25
Clarithromycin 0.125–1 0.125 0.125
Azithromycin 2–4 4 4
Erythromycin 0.25–2 2 2
Roxithromycin 0.25–4 4 4
Clindamycin ≤0.06–4 1 4
Penicillin G ≤0.06–0.25 ≤0.06 ≤0.06
Ampicillin-sulbactam ≤0.06–0.125 ≤0.06 0.125
Levofloxacin 0.25–2 0.25 0.5
Metronidazole 0.25–2 1 2
Clostridium spp. (16)f ABT-773 ≤0.06–>32 1 >32
Telithromycin ≤0.06–>32 1 >32
Clarithromycin 0.25–>32 32 >32
Azithromycin 0.5–>32 >32 >32
Erythromycin 1–>32 >32 >32
Roxithromycin 1–>32 >32 >32
Clindamycin 0.125–>32 4 8
Penicillin G ≤0.06–2 0.25 2
Ampicillin-sulbactam ≤0.06–2 0.125 1
Levofloxacin 0.15–16 4 8
Metronidazole 0.25–8 0.5 1
Peptostreptococcus spp. (39)g ABT-773 ≤0.06–>32 ≤0.06 ≤0.06
Telithromycin ≤0.06–>32 ≤0.06 ≤0.06
Clarithromycin ≤0.06–>32 0.5 0.5
Azithromycin ≤0.06–>32 0.5 4
Erythromycin ≤0.06–>32 0.5 2
Roxithromycin ≤0.06–>32 1 4
Clindamycin ≤0.06–32 0.125 0.5
Penicillin G ≤0.06–1 ≤0.06 0.125
Ampicillin-sulbactam ≤0.06–0.5 ≤0.06 0.25
Levofloxacin 0.125–0.5 0.25 1
Metronidazole 0.25–>32 0.5 >32
B. distasonis (15) ABT-773 0.125–>32 2 >32
Telithromycin 1–>32 8 >32
Clarithromycin 0.5–>32 4 >32
Azithromycin 32–>32 >32 >32
Erythromycin 4–>32 32 >32
Roxithromycin 0.5–>32 32 >32
Clindamycin 0.5–>32 8 >32
Penicillin G 8–>32 16 >32
Ampicillin-sulbactam 2–>32 4 16
Levofloxacin 0.5–4 1 4
Metronidazole 0.5–2 1 2
B. fragilis (20) ABT-773 2–16 8 8
Telithromycin 8–>32 16 32
Clarithromycin 1–8 4 8
Azithromycin 32–>32 >32 >32
Erythromycin 8–>32 32 >32
Roxithromycin 4–>32 >32 >32
Clindamycin 0.25–16 1 2
Penicillin G 4–>32 8 16
Ampicillin-sulbactam 0.5–8 1 4
Levofloxacin 0.5–4 1 2
Metronidazole 0.25–1 0.5 1
B. ovatus (15) ABT-773 0.5–>32 4 >32
Telithromycin 1–>32 16 >32
Clarithromycin 0.5–>32 8 >32
Azithromycin 32–>32 >32 >32
Erythromycin 2–>32 32 >32
Roxithromycin 4–>32 >32 >32
Clindamycin 0.5–>32 4 >32
Penicillin G 1–>32 8 >32
Ampicillin-sulbactam 0.5–16 1 16
Levofloxacin 1–16 4 8
Metronidazole 0.5–2 1 2
B. thetaiotaomicron (16) ABT-773 1–>32 4 >32
Telithromycin 2–>32 8 >32
Clarithromycin 2–>32 8 >32
Azithromycin 32–>32 >32 >32
Erythromycin 2–>32 8 >32
Roxithromycin 16–>32 >32 >32
Clindamycin 1–>32 4 >32
Penicillin G 8–>32 16 >32
Ampicillin-sulbactam 1–16 1 4
Levofloxacin 1–4 4 4
Metronidazole 0.5–1 0.5 1
B. uniformis (17) ABT-773 0.5–>32 4 >32
Telithromycin 1–>32 8 >32
Clarithromycin 0.5–>32 4 >32
Azithromycin 4–>32 >32 >32
Erythromycin 2–>32 16 >32
Roxithromycin 4–>32 >32 >32
Clindamycin 1–>32 2 >32
Penicillin G 4–>32 16 >32
Ampicillin-sulbactam 1–4 2 4
Levofloxacin 1–8 4 8
Metronidazole 0.25–2 1 2
B. vulgatus (16) ABT-773 0.125–8 0.25 4
Telithromycin 0.5–>32 1 >32
Clarithromycin 0.5–>32 1 >32
Azithromycin 8–>32 32 >32
Erythromycin 2–>32 4 >32
Roxithromycin 2–>32 4 >32
Clindamycin ≤0.06–>32 0.25 >32
Penicillin G 0.5–>32 8 >32
Ampicillin-sulbactam 0.5–0.16 1 16
Levofloxacin 1–2 1 2
Metronidazole 0.25–2 1 2
Bilophila wadsworthia (17) ABT-773 0.25–2 0.5 2
Telithromycin ≤0.06–2 1 2
Clarithromycin 1–8 4 8
Azithromycin 1–8 2 4
Erythromycin 2–32 8 16
Roxithromycin 1–32 4 32
Clindamycin ≤0.06–4 0.5 2
Penicillin G 0.5–>32 4 >32
Ampicillin-sulbactam 0.25–8 2 4
Levofloxacin ≤0.06–0.5 0.5 0.5
Metronidazole ≤0.06–0.125 ≤0.06 ≤0.06
B. ureolyticus-C. gracilis group (22)h ABT-773 0.25–8 0.5 1
Telithromycin ≤0.06–8 1 2
Clarithromycin 0.25–>32 2 4
Azithromycin ≤0.06–8 0.125 2
Erythromycin 0.125–>32 1 16
Roxithromycin 1–32 4 16
Clindamycin 0.125–16 2 8
Penicillin G ≤0.06–>32 16 >32
Ampicillin-sulbactam ≤0.06–>32 4 32
Levofloxacin 0.25–32 0.25 0.5
Metronidazole ≤0.06–>32 2 >32
F. nucleatum (13) ABT-773 0.5–16 2 8
Telithromycin 0.25–32 4 32
Clarithromycin 4–>32 16 >32
Azithromycin 0.25–8 1 8
Erythromycin 4–>32 16 >32
Roxithromycin 1–>32 >32 >32
Clindamycin ≤0.06–≤0.06 ≤0.06 ≤0.06
Penicillin G ≤0.06–0.125 ≤0.06 ≤0.06
Ampicillin-sulbactam ≤0.06–0.5 ≤0.06 0.25
Levofloxacin ≤0.06–1 0.5 1
Metronidazole ≤0.06–0.5 0.125 0.125
F. mortiferum-F. varium group (10)i ABT-773 32–>32 >32 >32
Telithromycin 32–>32 >32 >32
Clarithromycin >32–>32 >32 >32
Azithromycin 16–>32 32 >32
Erythromycin >32–>32 >32 >32
Roxithromycin >32–>32 >32 >32
Clindamycin ≤0.06–16 0.125 8
Penicillin G ≤0.06–>32 0.125 0.5
Ampicillin-sulbactam ≤0.06–32 1 2
Levofloxacin 0.5–8 1 4
Metronidazole ≤0.06–0.125 0.5 1
Fusobacterium spp. (5)j ABT-773 0.125–1 0.5
Telithromycin 0.5–2 1
Clarithromycin 2–8 4
Azithromycin 0.125–16 2
Erythromycin 1–16 8
Roxithromycin 1–32 8
Clindamycin 0.5–2 1
Penicillin G 0.5–16 4
Ampicillin-sulbactam 0.5–4 2
Levofloxacin 0.25–1 0.5
Metronidazole ≤0.06–2 ≤0.06
P. asaccharolytica (7) ABT-773 ≤0.06–≤0.06 ≤0.06
Telithromycin ≤0.06–≤0.06 ≤0.06
Clarithromycin ≤0.06–4 ≤0.06
Azithromycin 0.25–8 0.5
Erythromycin ≤0.06–2 0.25
Roxithromycin ≤0.06–8 0.125
Clindamycin ≤0.06–≤0.06 ≤0.06
Penicillin G ≤0.06–≤0.06 ≤0.06
Ampicillin-sulbactam ≤0.06–≤0.06 ≤0.06
Levofloxacin ≤0.06–0.5 0.5
Metronidazole ≤0.06–0.25 ≤0.06
P. bivia (10) ABT-773 ≤0.06–0.125 ≤0.06 0.125
Telithromycin ≤0.06–2 0.25 2
Clarithromycin ≤0.06–2 0.125 2
Azithromycin ≤0.06–>32 1 2
Erythromycin ≤0.06–>32 2 4
Roxithromycin ≤0.06–>32 0.5 2
Clindamycin ≤0.06–2 ≤0.06 ≤0.06
Penicillin G ≤0.06–16 8 16
Ampicillin-sulbactam ≤0.06–2 0.25 1
Levofloxacin 0.5–4 2 2
Metronidazole 0.25–4 2 4
Prevotella spp. (19)k ABT-773 ≤0.06–0.5 ≤0.06 0.5
Telithromycin ≤0.06–8 0.5 1
Clarithromycin ≤0.06–8 0.25 1
Azithromycin ≤0.125–>32 1 8
Erythromycin ≤0.125–32 1 8
Roxithromycin ≤0.06–8 1 4
Clindamycin ≤0.06–0.5 ≤0.06 0.25
Penicillin G ≤0.06–32 ≤0.06 8
Ampicillin-sulbactam ≤0.06–2 0.125 1
Levofloxacin 0.25–4 0.5 1
Metronidazole 0.5–2 1 2
a

MIC90s were calculated for a minimum of 10 strains. 

b

Actinomyces gerencseriae (1 isolate), A. israelii (2), A. meyeri (3), A. odontolyticus (1), and one isolate not identified to species level. 

c

Eubacterium lentum; some of these strains may be Eggerthella lenta (15 isolates), Eubacterium aerofaciens (1), or Eubacterium limosum (1). One isolate was not identified to species level. 

d

Lactobacillus acidophilus (4 isolates), L. brevis (2), L. casei (2), L. fermentum (7), L. jensenii (1), L. minutus (Atopobium minutum) (1), L. plantarum (3), L. rhamnosus (1), and L. uli (1). 

e

Propionibacterium acnes (12 isolates) and 4 isolates not identified to species level. 

f

Clostridium bifermentans (1 isolate), C. clostridioforme (1), C. hastiforme (1), C. novyi (1), C. paraputrificum (1), C. ramosum (9), C. subterminale (1), and 1 isolate not identified to species level. 

g

Peptostreptococcus anaerobius (7 isolates), P. magnus (1), P. micros (24), P. prevotii (3), anaerobic Streptococcus intermedius (1), anaerobic S. constellatus (1), and 2 Pepstreptococcus isolates not identified to species level. 

h

B. ureolyticus (4 isolates) and Campylobacter gracilis (18). 

i

F. mortiferum (4 isolates) and F. varium (6). 

j

Fusobacterium russii (1 isolate) and 4 isolates not identified to species level.   k Prevotella buccae (7 isolates), P. heparinolytica (1), P. intermedia (6), P. melaninogenica (4), and P. oris (1).