Table 1.
Family Criteria | |
1 | ≥2 cases of gastric cancer in family, independent of age at least >1 proven diffuse subtype 1 |
2 | ≥1 case of diffuse type gastric cancer any age and ≥1 case of lobular breast cancer diagnosed <70 years of age in different family members 1 |
3 | ≥2 cases of lobular breast cancer in family (both diagnosed <50 years of age) 1 |
Individual Criteria | |
1 | Individuals with diffuse type gastric cancer aged <50 years. |
2 | Gastric in situ signet ring cells and/or pagetoid spread of signet ring cells in individuals aged <50 years of age |
3 | Diffuse type gastric cancer at any age in individuals with a personal or family history (first-degree relative) of cleft lip/cleft palate |
4 | History of diffuse type gastric cancer and lobular breast cancer, both diagnosed <70 years of age |
5 | Bilateral lobular breast cancer/lobular carcinoma in situ, both diagnosed <70 years of age |
6 | Diffuse type gastric cancer at any age in individuals of Maori ethnicity Table 1: Genetic testing criteria according to the consensus meeting of IGLCL (Blair et al. 2020, [10]). 1 Family members must be first- or second-degree blood relatives (according to Blair et al. 2020 [10]). |
1 Family members must be first- or second-degree blood relatives (according to Blair et al. 2020 [10]).