Table 4.
Association between the baseline clinical, imaging, histopathological features and intra-individual MIB-1 labeling index differences in primary and recurrent meningiomas. Significant results (p < 0.05) are shown in bold type.
| Variable | Smaller or Equal MIB-1 Index (n = 10) | Increased MIB-1 Index (n = 6) | p-Value |
|---|---|---|---|
| Age | 0.63 | ||
| ≥54 | 5 | 2 | |
| <54 | 5 | 4 | |
| Sex | 0.035 | ||
| Male | 2 | 5 | |
| Female | 8 | 1 | |
| Tumor volume | 0.99 | ||
| <46 cm3 | 5 | 3 | |
| ≥46 cm3 | 5 | 3 | |
| Peritumoral edema | 0.99 | ||
| Present | 8 | 3 | |
| Not present | 3 | 2 | |
| Multiple meningioma | 0.23 | ||
| Present | 4 | 0 | |
| Not present | 6 | 6 | |
| Tumor localization | 0.60 | ||
| Skull base | 2 | 2 | |
| Non-skull base | 8 | 4 | |
| Sinus invasion | 0.06 | ||
| Present | 0 | 3 | |
| Not present | 9 | 4 | |
| Brain invasion | 0.99 | ||
| Present | 0 | 2 | |
| Not present | 5 | 9 | |
| Primary MIB-1 index | 0.33 | ||
| ≥9% | 8 | 3 | |
| <9% | 3 | 4 | |
| Primary mitotic count | 0.99 | ||
| ≥4 | 5 | 3 | |
| <4 | 5 | 3 | |
| CD68+ macrophage infiltrates | 0.001 | ||
| Focal | 10 | 1 | |
| Diffuse | 0 | 5 | |
| Simpson grade | 0.63 | ||
| Simpson grades I and II | 9 | 5 | |
| Simpson grade ≥ III | 1 | 1 | |
| WHO grade | 0.61 | ||
| 1 | 6 | 2 | |
| 2 | 4 | 4 | |
| Mean serum C-reactive protein level (+/− SD) | 2.73 +/− 3.35 | 1.02 +/− 1.19 | 0.30 |
| Mean plasma fibrinogen level (+/− SD) | 3.67 +/− 0.73 | 2.23 +/− 0.38 | 0.02 |