Table 1.
Summary of nanoparticles for PTT.
| PTT Agent (Formulation or Modification) |
Properties | Treatment Temp. |
Laser Wavelength, Duration |
Tumor Model | Therapeutic Effect |
Ref. | ||
|---|---|---|---|---|---|---|---|---|
| Size (nm) | Absorption Max. (nm) |
|||||||
| Organic dye nanoparticles | ICG (PLGA, lipid, doxorubicin) |
90 | 815 nm | 53 °C | 808 nm, 5 min |
MCF-7 | Apoptosis | [56] |
| ICG (cholesterol, lipid, folic acid) |
20~40 | 810 nm | 50 °C | 808 nm, 5 min |
MCF-7 | Necrosis | [57] | |
| ICG (human serum albumin) |
80 | 816 nm | 57 °C | 785 nm, 5 min |
4T1 | Necrosis | [58] | |
| Naphthalocyanine (PEG-PCL, Si) |
40 | 785 nm | 47 °C | 785 nm, 10 min |
A2780/AD | Apoptosis | [59] | |
| Naphthalocyanine (F127) |
30 | 860 nm | 60 °C | 860 nm, 10 min |
4T1 | Photothermal ablation | [60] | |
| Porphyrin (Dendrimer form + PEG) |
20 | 650–690 | 57 °C | 690 nm, 2 min |
SKOV3 | Necrosis | [61] | |
| ICG (PLGA, R848) |
160 | 780 nm | 50 °C | 808 nm, 10 min |
RM9 | Immune response |
[62] | |
| ICG (thymopentin) |
30 | broad | 47 °C | 808 nm, 10 min |
Pan02 | Immune response |
[63] | |
| Inorganic nanoparticles | Iron oxide nanoparticle | 20 | broad | 56 °C | 808 nm, 3 min |
A549 | Apoptosis | [72] |
| Iron oxide nanoparticle (doxorubicin) |
10–310 | 480 nm (DOX) |
57 °C | 808 nm, 3 min |
MCF-7 S180 |
Apoptosis and necrosis | [73] | |
| Iron oxide nanoparticle (polypyrrole) |
100 | broad | 58 °C | 808 nm, 5 min |
4T1 | Photothermal ablation | [74] | |
| Carbon nanotube, MW (chitosan, doxorubicin) |
250 | broad | 67 °C | 808 nm, 5 min |
Bel-7402 | Photothermal ablation | [76] | |
| Carbon nanotube, SW (PEG) |
- | borad | 55 °C | 808 nm, 10 min |
4T1 | Photothermal ablation | [79] | |
| Carbon nanotube, SW (hyaluronic acid, cholanic acid, PEG, ICG) |
390 | broad | 55 °C | 808 nm, 10 min |
SCC-7 | Necrosis | [80] | |
| Graphene oxide (PEG) |
10~50 | broad | 50 °C | 808 nm, 5 min |
4T1 | Photothermal ablation | [82] | |
| Iron oxide nanoparticle (PLGA-PEG, R837,) |
150 | 320 nm | <50 °C | 808 nm, 10 min |
4T1 | Immune respones | [83] | |
| Iron oxide nanoparticle (PLGA-PEG, pentafluoropentane, anti-PD-1) |
220 | 700 nm | 45 °C | 660 nm, 10 min |
B16F10 | ICD | [84] | |
| Carbon nanotube, MW (CpG or doxorubicin) |
200 | 480 nm (DOX) |
46 °C | 808 nm, 3 min |
B16 | ICD | [85] | |
| Graphene oxide (IDO inhibitor, anti-PD-L1) |
200 | broad | 53 °C | 808 nm, 8 min |
CT26 | Immune response | [86] | |
| Metallic nanoparticles | Gold nanosphere (anti-EGFR antibody) |
40 | 530 nm | - | 514 nm, 4 min |
HSC 313 HSC 3 |
Photothermal ablation | [97] |
| Gold nanoshell (PEG) |
300 | 550 nm | 60 °C | 808 nm, 10 min |
U-87 MG | Necrosis | [103] | |
| Gold nanocage (PEG) |
90 | 800 nm | 54 °C | 808 nm, 10 min |
U87MGwtEGFR | Necrosis | [104] | |
| Gold nanostar (PEG) |
30 | 945 nm | 50 °C | 980 nm, 10 min |
Sarcoma | Necrosis | [106] | |
| Gold nanorod (peptide, Cy5.5) |
- | 670 nm | 45 °C | 670 nm, 4 min |
SCC-7 | Photothermal ablation | [110] | |
| Gold nanosphere (liposome) |
100 | 964 nm | 50 °C | 1064 nm, 10 min |
4T1 | ICD | [49] | |
| Gold nanoshell (PEG) |
40 | 808 nm | - | 808 nm, 3 min |
B16-F10 | ICD | [111] | |
| Gold nanocage (anti-PDL1, galunisertib) |
60 | 800 nm | 45 °C | 808 nm, 10 min |
CT26 | ICD | [112] | |
| Gold nanocage (MnO2) |
90 | 740 nm | 50 °C | 808 nm, 3 min |
4T1 | ICD | [113] | |
| Gold nanostar (selenium) |
120 | 850 nm | 52 °C | 808 nm, 10 min |
U14 | ICD | [114] | |
| Gold nanostar (doxorubicin) |
150 | 775 nm | <50 °C | 808 nm, 5 min |
CT26 | ICD | [115] | |
| Gold nanorod (MnO2) |
80 × 20 | 808 nm | 50 °C | 808 nm, 5 min |
4T1 | ICD | [116] | |