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. 2022 Apr 13;14(8):1966. doi: 10.3390/cancers14081966

Table 7.

The analysis of the available scoring scales (NA—data not available).

Authors of the Study Analyzed Parameters Number of Patients Sensitivity Specificity Other
Nagai et al. [47]. Age, LDH, MRI, endometrial cytology finding 63 patients with suspected uterine sarcoma (after pathological examination: 15 with uterine sarcoma and 48 with benign tumors) 80% 85.4%
Köhler et al. [12]. Bleeding symptoms: intermenstrual bleeding, hypermenorrhea, dysmenorrhea, postmenstrual bleeding, suspicious sonography and the tumor diameter 826 patients with LM, 239 patients with LMS 87.5% 94.23%
Nishigaya et al. [48]. Preoperative serum concentrations of LDH, D-dimer, CRP 69 cases of LM, 36 cases of LMS and 28 cases of presumed malignancy 35.3% 100% (when all parameters were positive)
Thomassin-Naggara et al. [87]. Clinical parameters: the age of the patient, menopausal status and MRI parameters including high b1000 signal intensity, intermediate T2-weighted signal intensity, mean, intra-tumoral hemorrhage, endometrial thickening, T2-weighted signal heterogeneity, heterogeneous enhancement and non-myometrial origin 51 patients, including 15 patients with LM and 3 patients with LMS NA NA
Zhang Fenfen al [39]. Preoperative serum concentrations of CA125, LDH, HE4 37 participants with LMS and 102 participants with DUF 68.4% 95.1%
Goto et al. [45]. LDH and MRI 227 patients including 10 patients with LMS and 130 patients with ULM and 17 patients with DULM 100% 99.2%
Zhang Guorui et al. [49]. Age ≥ 40 years old, tumor size ≥ 7 cm, neutrophil-to-lymphocyte ratio (NLR) ≥ 2.8, number of platelet ≥ 298 × 109/L and lactate dehydrogenase (LDH) ≥ 193 U/L 45 ULMS patients and 180 uterine fibroid patients 80%
(in the cut-off value—4 points)
77.8% (in the cut-off value—4 points)
Lawlor et al. [113]. Postmenopausal status, symptoms of pressure, postmenopausal bleeding, neutrophil count ≥ 7.5 × 109, hemoglobin level < 118 g/L, endometrial biopsy results of cellular atypia or neoplasia, and a mass size of ≥10 cm on radiological imaging 190 patients including 159 ULM and 31 ULMS NA NA
Wang et al. [118]. Three clinical parameters: the age, menopausal status, and symptoms and seven radiomic features 134 patients including 81 with LM and 53 malignant uterine mesenchymal tumors NA NA The AUC value was the highest when the radiomics model was combined with clinical model to 0.91 ± 0.05 (p < 0.05)