Table 7.
Authors of the Study | Analyzed Parameters | Number of Patients | Sensitivity | Specificity | Other |
---|---|---|---|---|---|
Nagai et al. [47]. | Age, LDH, MRI, endometrial cytology finding | 63 patients with suspected uterine sarcoma (after pathological examination: 15 with uterine sarcoma and 48 with benign tumors) | 80% | 85.4% | |
Köhler et al. [12]. | Bleeding symptoms: intermenstrual bleeding, hypermenorrhea, dysmenorrhea, postmenstrual bleeding, suspicious sonography and the tumor diameter | 826 patients with LM, 239 patients with LMS | 87.5% | 94.23% | |
Nishigaya et al. [48]. | Preoperative serum concentrations of LDH, D-dimer, CRP | 69 cases of LM, 36 cases of LMS and 28 cases of presumed malignancy | 35.3% | 100% (when all parameters were positive) | |
Thomassin-Naggara et al. [87]. | Clinical parameters: the age of the patient, menopausal status and MRI parameters including high b1000 signal intensity, intermediate T2-weighted signal intensity, mean, intra-tumoral hemorrhage, endometrial thickening, T2-weighted signal heterogeneity, heterogeneous enhancement and non-myometrial origin | 51 patients, including 15 patients with LM and 3 patients with LMS | NA | NA | |
Zhang Fenfen al [39]. | Preoperative serum concentrations of CA125, LDH, HE4 | 37 participants with LMS and 102 participants with DUF | 68.4% | 95.1% | |
Goto et al. [45]. | LDH and MRI | 227 patients including 10 patients with LMS and 130 patients with ULM and 17 patients with DULM | 100% | 99.2% | |
Zhang Guorui et al. [49]. | Age ≥ 40 years old, tumor size ≥ 7 cm, neutrophil-to-lymphocyte ratio (NLR) ≥ 2.8, number of platelet ≥ 298 × 109/L and lactate dehydrogenase (LDH) ≥ 193 U/L | 45 ULMS patients and 180 uterine fibroid patients | 80% (in the cut-off value—4 points) |
77.8% (in the cut-off value—4 points) | |
Lawlor et al. [113]. | Postmenopausal status, symptoms of pressure, postmenopausal bleeding, neutrophil count ≥ 7.5 × 109, hemoglobin level < 118 g/L, endometrial biopsy results of cellular atypia or neoplasia, and a mass size of ≥10 cm on radiological imaging | 190 patients including 159 ULM and 31 ULMS | NA | NA | |
Wang et al. [118]. | Three clinical parameters: the age, menopausal status, and symptoms and seven radiomic features | 134 patients including 81 with LM and 53 malignant uterine mesenchymal tumors | NA | NA | The AUC value was the highest when the radiomics model was combined with clinical model to 0.91 ± 0.05 (p < 0.05) |