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. 2022 Apr 14;10(4):612. doi: 10.3390/vaccines10040612

Figure 1.

Figure 1

Flow cytometry analysis of DENV-specific CD8+ T cells in DENV hospitalized donors. (a) Gating strategy. (b) Magnitude of CD3 + CD8+ IFNγ+ T cells responses as a function of disease severity. (c) Magnitude of CD3 + CD8+ IFNγ+ T cells responses as a function of days post fever onset (PFO). (d) Median percentage of CD3 + CD8+ IFNγ+ T cells compared to previous data generated on CD3 + CD4 + IFNγ+ T cells (3). (e) Memory phenotype of CD3 + CD8+ T cells in the IFNγ− and IFNγ+ compartments as a function of disease severity. In white, DF donors, in black DHF. ** p < 0.01; ns = not significant. Statistical comparisons performed with Mann–Whitney test. N = naïve; CM = central memory; EM = effector memory; Temra = terminal differentiated effector memory cells.