Table 3.
Summary of cardiovascular phenotypes in Crk and/or Crkl null and NCC cko embryos
| Genotypes | Embryonic lethality | Dilated common carotid artery | Cardiac OFT defect |
|---|---|---|---|
| Crkl−/− | E16.5 (17,18) |
No | DORV, TOF, VSD (50% penetrance) (17,18) |
| Crk−/− | E13.5–E15.5 (16) | Yes (16) | DORV, VSD (19) (N = 7, 100% penetrance at E15) |
| Wnt1-Cre/+; Crklf/f | No | No (N = 7) | No (N = 7) |
| Wnt1-Cre/+; Crkf/f | E16.5–P20 | No (N = 5) | DORV, VSD (N = 15, 60% penetrance at E15.5) |
| Wnt1-Cre/+; Crkf/+; Crklf/+ | No | No (N = 7, E12.5) | No (N = 7, E12.5) |
| Wnt1-Cre/+; Crkf/f; Crklf/+ | E12.5–E14 | Yes (N = 6, 100% penetrance at E12.5) |
OFT septation defect (N = 6, 100% penetrance at E12.5) |
| Wnt1-Cre/+; Crkf/+; Crklf/f | E12.5–E14 | Yes (N = 9, 78% penetrance at E12.5) |
OFT septation defect (N = 9, 100% penetrance at E12.5) |
| Wnt1-Cre/+; Crkf/f; Crklf/f | E11.5–E12.5 | Yes (N = 9, 100% penetrance at E11.5) |
OFT septation defect (N = 9, 100% penetrance at E11.5) |