Table 2.

Structure of ALS-31 derivatives and their effect on SmSOD activity.

Code	ID	n	m	R	R1	Residual SOD Activity (%) in the Presence of [Compound] (a)		IC50 (µM) (b)
						50 µM	100 µM
1098459	ALS-31-1	1	-	-		104.1	97.2	n.d.
1098464	ALS-31-2	1	-	-		89.8	113.1	n.d.
1098679	ALS-31-3	1	2	H		78.8	103.6	n.d.
1098687	ALS-31-4	-	-	-	-	92.6	96.8	n.d.
1098708	ALS-31-5	-	-	-	-	93.4	99.6	n.d.
1097658	ALS-31-6	-	3	-	-	75.1	78.0	127 ± 12
1097659	ALS-31-7	-	2	-	-	95.4	125.0	n.d.
1098702	ALS-31-8	2	2	CH3		69.2	76.9	292 ± 30
1099294	ALS-31-9	-	-	-	-	65.3	50.3	64 ± 15
6235929	ALS-31-10	2	-	-		75.0	68.9	139 ± 8
1098529	ALS-31-11	2	-	-		83.7	125.1	n.d.
1098688	ALS-31-12	2	1	H	H	75.6	125.3	n.d.

^(a) Activity of SmSOD in the absence of compound equal to 100. ^(b) Not determined.