Table 1. SNPs of the TLR3 gene associated with HBV.
| Polymorphism | Author | Year | population | Sample size | MAF(%) (controls) |
Influence on | References | |
|---|---|---|---|---|---|---|---|---|
| cases | controls | |||||||
|
rs1879026
(G/T) |
Al-Qahtani et al | 2012 | Saudi Arabian | 707 | 600 | 17.20 | Susceptibility to HBV infection | Al-Qahtani et al. (2012) |
| Huang et al | 2015 | Chinese Han | 437 | 186 | 28.00 | The risk of HBV-related liver diseases | Huang et al. (2015) | |
| rs1879026- rs5743313- rs5743314- rs5743315 haplotype | Al-Qahtani et al. | 2012 | Saudi Arabian | 707 | 600 | – | Susceptibility to HBV infection | Al-Qahtani et al. (2012) |
|
rs3775290
(C/T) |
Goktas et al. | 2016 | Turkish | 116 | 50 | 28.00 | Susceptibility to chronic hepatitis B | Goktas et al. (2016) |
| Sghaier et al. | 2019 | Tunisian | 274 | 360 | 35.60 | The risk of HBV-related HCC. | Sghaier et al. (2019) | |
| Huang et al. | 2015 | Chinese Han | 437 | 186 | 41.90 | The risk of HBV- relatedliver diseases | Huang et al. (2015) | |
| Gao et al. | 2015 | Chinese | 51 | 348 | 33.30 | Susceptibility to HBV intrauterine transmission | Gao et al. (2015) | |
|
rs3775291
(C/T) (G/A) |
Ye et al. | 2020 | Meta-Analysis | – | – | – | Susceptibility to HBV infection | Ye et al. (2020) |
| Rong et al. | 2013 | Chinese Han | 452 | 462 | 25.40 | Susceptibility to chronic hepatitis B infection and HBV-related ACLF | Rong et al. (2013) | |
| Geng et al. | 2016 | Meta- Analysis | 3547 | 2797 | – | The risk of HBV-related liver diseases | Geng et al. (2016) | |
| Li et al. | 2013 | Chinese | 466 | 482 | 25.82 | Susceptibility to HBV-related HCC. | Li & Zheng (2013) | |
| Chen et al. | 2017 | Chinese Han male | 688 | 686 | 36.95 | Susceptibility to HBV-related HCC. | Chen et al. (2017) | |
| Fischer et al. | 2018 | Caucasian | 860 | 254 | 24.00 | HBV clearance and susceptibility to HBV infection | Fischer et al. (2018) | |
| Sa et al. | 2015 | Brazilian | 109 | 299 | 33.10 | Susceptibility to HBV infection | Sa et al. (2015) | |
|
rs5743305
(T/A) |
Fischer et al. | 2017 | Caucasian | 494 | 1057 | – | Spontaneous HBsAg clearance | Fischer et al. (2018) |
| Chen et al. | 2017 | Chinese Han male | 688 | 686 | 30.05 | Susceptibility to HBV infection and HBV-related HCC. | Chen et al. (2017) , Li & Zheng (2013), Sa et al. (2015) | |
Notes.
Abbreviations
- MAF
- minor allele frequency
- HCC
- Hepatocellular carcinoma
- ACLF
- acute-on-chronic liver failure