Table 2.

Differentially methylated regions (DMRs) identified in the five brain regions.

	Chr	CpG	Gene	Dir 1	N Probes	Z P	Z Sidak p	Start	End
ACC	3	cg02834909	PRSS50	+	5	1.72 × 10−8	7.48 × 10−5	46,759,438	46,759,589
BA9	3	cg22909901	MCF2L2; B3GNT5	+	2	3.71 × 10−8	3.19 × 10−4	182,981,632	182,981,708
	6	cg23161317	ZNF192P1	−	6	3.17 × 10−9	1.20 × 10−5	28,129,313	28,129,486
	6	cg23681866	HCG4B	−	5	1.48 × 10−9	6.66 × 10−6	29,895,116	29,895,261
CN	1	cg10703826	TBX15	−	7	5.96 × 10−10	2.03 × 10−6	119,532,044	119,532,234
	12	cg26114124	LINC00612; A2M-AS1	−	8	3.02 × 10−12	5.60 × 10−9	9,217,510	9,217,860
	16	cg06751612	PIEZO1; LOC100289580	+	2	1.96 × 10−7	4.38 × 10−3	88,798,826	88,798,855
	5	cg11916729	SCGB3A1	+	6	2.81 × 10−7	1.82 × 10−3	180,018,465	180,018,565
PUT	12	cg02883147	LINC00612; A2M-AS1	−	5	9.86 × 10−9	3.58 × 10−5	9,217,669	9,217,860
	19	cg24716275	ZNF264	−	6	7.80 × 10−10	4.17 × 10−6	57,702,371	57,702,501
VS	3	cg00817731	PRSS50	+	5	1.71 × 10−7	7.52 × 10−4	46,759,438	46,759,589
	4	cg08064687	INPP4B	−	2	7.43 × 10−9	8.65 × 10−5	143,326,485	143,326,542
	6	cg14654363	-	−	8	1.00 × 10−9	4.28 × 10−6	28,601,365	28,601,520
	6	cg27596495	HCRTR2	+	4	1.37 × 10−8	6.00 × 10−5	55,039,232	55,039,383
	7	cg06036947	ADAP1	−	2	5.34 × 10−8	4.60 × 10−4	949,758	949,835
	7	cg07972322	C7orf49; TMEM140	−	5	4.84 × 10−10	1.23 × 10−6	134,832,770	134,833,032

DMRs associated with tobacco smoking in the anterior cingulate cortex (ACC), Brodmann Area 9 (BA9), caudate nucleus (CN), putamen (PUT) and ventral striatum (VS). Genes exhibiting DMRs within multiple brain regions are highlighted in bold type. Dir ¹: DMR characterized by hypermethylation (+) or hypomethylation (−) of probes.