Table 3.

Associations of the predictor CpG sites in blood and brain.

CpG Site	Gene	Blood * (n = 15,907)		ACC (n = 38)		BA9 (n = 72)		CN (n = 68)		PUT (n = 68)		VS (n = 65)
		β	pval	β	pval	β	pval	β	pval	β	pval	β	pval
cg05575921	AHRR	−0.180	4.55 × 10−26	−0.310	0.038	−0.158	0.163	−0.247	0.059	−0.220	0.033	−0.030	0.827
cg03636183	F2RL3	−0.095	1.12 × 10−20	−0.117	0.118	−0.010	0.834	−0.056	0.198	−0.016	0.619	−0.080	0.116
cg09935388	GFI1	−0.083	3.14 × 10−17	−0.162	0.345	−0.183	0.132	0.163	0.206	−0.060	0.595	0.142	0.369
cg12876356	GFI1	−0.057	1.49 × 10−15	0.022	0.838	−0.041	0.516	0.028	0.640	0.025	0.705	0.028	0.730
cg12803068	MYO1G	0.063	9.06 × 10−23	0.075	0.556	−0.045	0.598	0.101	0.163	0.082	0.292	0.014	0.810
cg13039251	PDZD2	0.030	1.36 × 10−15	0.060	0.673	−0.051	0.519	0.109	0.217	0.118	0.186	−0.014	0.894
cg01940273	-	−0.082	2.03 × 10−34	−0.015	0.895	−0.035	0.569	−0.008	0.903	0.007	0.885	−0.013	0.851
cg15693572	-	0.053	3.85 × 10−11	−0.120	0.297	0.068	0.478	0.113	0.227	−0.009	0.912	−0.030	0.800
cg21566642	-	−0.126	4.22 × 10−25	−0.205	0.202	−0.176	0.018	0.039	0.707	−0.147	0.119	0.048	0.628

For the nine CpG sites derived from Maas, Vidaki [28], effect sizes and p-values of the association analyses with smoking in blood (* EWAS from Joehanes, Just [5]) and the five brain regions are summarized. Nominally significant results are highlighted in bold type. Β, EWAS effect size; pval, EWAS p-value; ACC, anterior cingulate cortex; BA9, Brodmann Area 9; CN, caudate nucleus; PUT, putamen; VS, ventral striatum.