Table 1.

Histone acetylation and deacetylation are performed by KATs and HDACs, respectively. Two types of KATs are defined: type A and B. Type A KATs have a nuclear localization and modify chromatin-associated histones, whereas type B KATs, mainly localized at the cytoplasmic level, modify newly synthesized histones not incorporated in the nucleosome. KATs are classified into six families and HDACs into four.

Histone Acetyltransferase	TYPE B	TYPE A
	Cytoplasmic KAT Family	GNAT Family	P300/CBP Family	MYST Family	Transcription Factor Related Family	Nuclear Receptor Coactivator Family
	KAT1 (HAT1)	KAT2A (hGCN5)	KAT3A (CBP)	KAT5 (TIP60/PLIP)	KAT4 (TAF1)	KAT13A (SRC1)
		KAT2B (PCAF)	KAT3B (p300)	KAT6A (MOZ/MYST3)	KAT12 (TFIIIC90)	KAT13B (ACTR)
		KAT9 (ELP3)		KAT6B (MORF/MYST4)		KAT13C (P160)
				KAT7 (HBO1/MYST2)		KAT13D (CLOCK)
				KAT8 (HMOF/MYST1)
Histone Deacetylase	Class I	Class II		Class III	Class IV
	HDAC1	HDAC4		SIRT1	HDAC11
	HDAC2	HDAC5		SIRT2
	HDAC3	HDAC6		SIRT3
	HDAC8	HDAC7		SIRT4
		HDAC9		SIRT5
		HDAC10		SIRT6
				SIRT7