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. 2022 Apr 8;27(8):2409. doi: 10.3390/molecules27082409
ATCC American Type Culture Collection
ATP Adenosine triphosphate
BBB Blood–brain barrier
BCI-2 B-cell lymphoma 2
CBSI Colchicine-binding-site inhibitors
Log P Lipophilicity
Log S Solubility
MAPS Microtubule-associated proteins
MaxTc Max Tanimoto coefficients
MCF-10A Human breast epithelial cell line
MDA-MB-321 Human breast adenocarcinoma cell line
MMP Mitochondrial Membrane Potential
NA Not applicable
Pa Probability of being active
PASS Plan for Achieving Self Support
Pi Probability of being inactive
PRa Progesterone receptor alpha
RMSD Root-mean-square deviation
SEA Similarity ensemble approach
SP Standard precision
VEGF Vascular endothelial growth factor
XP Extra precision
3D Three dimensional
ABC ATP-binding cassette
ADME Absorption, Distribution, Metabolism, and Excretion.
AKT-PI3 protein kinase B/Phosphoinositide 3-kinase
CYP Cytochrome P450
DFF-45 DNA fragmentation factor 45
ER-LBD Estrogen Receptor Ligand-Binding Domain
Era Estrogen receptor alpha
HBSS Hank’s Balanced Salt Solution
HCI High content imagining
HCT8 Human ileocecal adenocarcinoma cell line
HL60 Human leukemia cell line
HTS High-throughput screening
IC50 Half-maximal inhibitory concentration
JAK-STAT Janus Kinase/Signal Transducer and Activator of Transcription.
KAIMRC1 King Abdullah international medical research center 1 cell line
KAIMRC2 King Abdullah international medical research center 1 cell line
LD Lethal dose