ATCC |
American Type Culture Collection |
ATP |
Adenosine triphosphate |
BBB |
Blood–brain barrier |
BCI-2 |
B-cell lymphoma 2 |
CBSI |
Colchicine-binding-site inhibitors |
Log P |
Lipophilicity |
Log S |
Solubility |
MAPS |
Microtubule-associated proteins |
MaxTc |
Max Tanimoto coefficients |
MCF-10A |
Human breast epithelial cell line |
MDA-MB-321 |
Human breast adenocarcinoma cell line |
MMP |
Mitochondrial Membrane Potential |
NA |
Not applicable |
Pa |
Probability of being active |
PASS |
Plan for Achieving Self Support |
Pi |
Probability of being inactive |
PRa |
Progesterone receptor alpha |
RMSD |
Root-mean-square deviation |
SEA |
Similarity ensemble approach |
SP |
Standard precision |
VEGF |
Vascular endothelial growth factor |
XP |
Extra precision |
3D |
Three dimensional |
ABC |
ATP-binding cassette |
ADME |
Absorption, Distribution, Metabolism, and Excretion. |
AKT-PI3 |
protein kinase B/Phosphoinositide 3-kinase |
CYP |
Cytochrome P450 |
DFF-45 |
DNA fragmentation factor 45 |
ER-LBD |
Estrogen Receptor Ligand-Binding Domain |
Era |
Estrogen receptor alpha |
HBSS |
Hank’s Balanced Salt Solution |
HCI |
High content imagining |
HCT8 |
Human ileocecal adenocarcinoma cell line |
HL60 |
Human leukemia cell line |
HTS |
High-throughput screening |
IC50
|
Half-maximal inhibitory concentration |
JAK-STAT |
Janus Kinase/Signal Transducer and Activator of Transcription. |
KAIMRC1 |
King Abdullah international medical research center 1 cell line |
KAIMRC2 |
King Abdullah international medical research center 1 cell line |
LD |
Lethal dose |