Table 1.

Immunological abnormalities in patients with double stranded DNA repair disorders.

Laboratory Parameter	AT	NBS
IgG level	N/↓	N/↓
IgG2/or IgG4/or IgG1 level	↓	↓
IgM level	N/↓/↑	N/↓/↑
IgA level	Absent/↓	Absent/↓
IgE level	Absent/↓	Absent/↓
Number of CD3+ T cells	N/↓	N/↓
Number of CD4+ T cells	N/↓	N/↓
Number of CD8+ T cells	N/↓	N/↓
Number of CD19+ B cells	N/↓	N/↓
Number of CD16/56+ NK cells	N	N
Number of CD4 + CD45 RA+ cells	↓	↓
TREC and KREC levels	↓	↓
Mitogen induced T and B cell responses	N/↓	↓
Response to protein Ag	↓	↓
Response to polysaccharide Ag	↓	↓
TCR γδ T cells

Abbreviations: TREC, T-cell recombination excision circles; KREC, kappa-deleting element recombination circle; TCR, T-cell receptor; Ag, antigen; N, normal; AT, Ataxia Telangiectasia; NBS, Nijmegen breakage syndrome.