Table 2.
Changes in concentrations and estimates of renal health and function biomarkers.
| Variable | Baseline | Post-Exercise | Delta | t-Value | p-Value |
|---|---|---|---|---|---|
| Entire Cohort | |||||
| SCr (mg/dL) | 0.92 ± 0.23 | 0.91 ± 0.23 | 1.1% | −1.15 | 0.259 |
| uCR (mg/dL) | 145.5 ± 104.5 | 178.1 ± 138.7 | 22.4% | 2.07 | 0.046 * |
| CyC (ng/mL) | 611.82 ± 80.15 | 714.5 ± 167.12 | 16.8% | 4.24 | 0.0001 * |
| uEGF (ng/mL) | 6574.16 ± 1519.64 | 6780.0 ± 1467.1 | 3.1% | 0.94 | 0.353 |
| uEGF/uCR (ng/mL)/(mg/dL) | 1.56 ± 0.81 | 1.94 ± 1.33 | 24.4% | 1.71 | 0.096 |
| eGFR (MDRD) | 98.46 ± 35.12 | 83.41 ± 32.60 | 15.3% | −1.75 | 0.089 |
| eGFR (CKD-EPI) | 102.34 ± 45.78 | 107.90 ± 53.35 | 5.5% | 1.23 | 0.229 |
| eGFR (CyC) | 142.80 ± 21.87 | 124.07 ± 31.82 | 13.1% | −3.94 | 0.0004 * |
| eGFR (CyC and SCr) | 118.97 ± 23.05 | 113.47 ± 25.58 | 4.6% | −0.96 | 0.346 |
| Group 1 (20–39) | |||||
| SCr (mg/dL) | 0.96 ± 0.24 | 0.92 ± 0.25 | 3.4% | 1.107 | 0.280 |
| uCR (mg/dL) | 150.68 ± 105.30 | 195.86 ± 144.67 | 29.9% | −1.97 | 0.061 |
| CyC (ng/mL) | 614.83 ± 83.13 | 730.92 ± 185.50 | 18.9% | −3.70 | 0.001 * |
| uEGF (ng/mL) | 6717.43 ± 1540.43 | 6934.24 ± 1436.27 | 3.2% | −0.782 | 0.442 |
| uEGF/uCR (ng/mL)/(mg/dL) | 1.54 ± 0.84 | 1.83 ± 1.01 | 18.83% | −1.75 | 0.094 |
| eGFR (MDRD) | 105.67 ± 37.02 | 87.47 ± 32.18 | 17.2% | 1.81 | 0.084 |
| eGFR (CKD-EPI) | 103.1 ± 42.12 | 114.57 ± 52.68 | 11.1% | −1.05 | 0.303 |
| eGFR (CyC) | 147.74 ± 22.03 | 126.57 ± 32.55 | 14.3% | 4.12 | 0.001 * |
| eGFR (CyC and SCr) | 122.71 ± 21.97 | 118.13 ± 25.59 | 3.7% | 1.11 | 0.280 |
| Group 2 (40–59) | |||||
| SCr (mg/dL) | 0.93 ± 0.18 | 0.89 ± 0.19 | 4.3% | 0.616 | 0.551 |
| uCR (mg/dL) | 137.69 ± 101.14 | 153.92 ± 123.48 | 11.8% | −1.24 | 0.235 |
| CyC (ng/mL) | 616.32 ± 77.16 | 704.43 ± 129.78 | 14.3% | −2.63 | 0.020 * |
| uEGF (ng/mL) | 6255.81 ± 1420.11 | 6458.86 ± 1441.45 | 3.2% | −0.64 | 0.535 |
| uEGF/uCR (ng/mL)/(mg/dL) | 1.59 ± 0.74 | 1.64 ± 0.95 | 3.1% | −0.43 | 0.672 |
| eGFR (MDRD) | 78.22 ± 14.24 | 75.79 ± 31.52 | 3.1% | 0.278 | 0.786 |
| eGFR (CKD-EPI) | 84.64 ± 20.95 | 97.92 ± 52.32 | 15.7% | −0.919 | 0.378 |
| eGFR (CyC) | 132.69 ± 18.55 | 116.90 ± 29.77 | 11.9% | 1.84 | 0.088 |
| eGFR (CyC and SCr) | 105.91 ± 12.56 | 104.36 ± 21.71 | 1.5% | 0.205 | 0.841 |
Abbreviations: Cystatin C (CyC), chronic kidney disease—epidemiology (CKD_EPI), estimated glomerular filtration rate (eGFR), modification of diet in renal disease (MDRD), serum creatinine (SCr), urine creatinine (uCR), and urine epidermal growth factor (uEGF). All eGFR equations are presented as mL/min/1.73 m2 units. All data are presented as mean + standard error (SE). * Indicates significant p < 0.05 differences pre—to post-exercise.