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. 2022 Apr 21;12:13. doi: 10.5334/tohm.686

Table 2.

Ataxic and non ataxic features of patients with SCA 12.


Age at onset: 46.38 ± 11.7 years

Duration of illness: 9.20 ± 9.5 years

Age at presentation: 53.16 ± 12.78 years

Symptom at onset: Total numbers %

              Tremors 36 73.5%

              Ataxia 9 18.4%

              Myoclonus 3 6.1%

              Behavioural changes 1 2%

Symptom at presentation

              Tremors 47 95.9%

              Ataxia 36 73.5%

              Cognitive dysfunction 11 22.4%

              Urinary disturbance 10 20.4%

              Psychiatric disturbance 4 8.1%

              Myoclonus 3 6%

              Extrapyramidal symptoms 3 6%

              Sensory Symptoms 1 2%

Tremor 47 95.9%

Duration 7.13 ± 4.28 years

Side and site at onset

              Right UL 26 53.1%

              Bilateral 17 34.7%

              Left UL 2 4.1%

              Head 2 4.1%

Side of appendicular tremor at presentation

              Bilateral
              –Symmetrical
              –Right>Left
42
–35
–7
85.7%
–71.4%
–14.3%

              Right UL 2 4.1%

              Head 2 4.1%

              Left UL 1 2%

Type of tremor

              Postural 43 87.7%

              Intentional 28 57.1%

              Kinetic 13 26.5%

              Rest 18 36.7%

Head tremor 27 55.1%

Voice tremor 21 42.8%

Jaw tremor 5 10.2%

Tongue tremor 5 10.2%

History of Imbalance at presentation 36 73.5%

Duration 4.88 ± 3.86 years

Ataxia on examination 44 89.8%

              Impaired tandem gait 44 89.8%

              Dysmetria 37 75.5%

              Dyssynergia 33 67.3%

              Dysdiadokinesia 33 67.3%

              Dysarthria 28 57.1%

              Saccadic abnormality 13 26.5%

              Broken pursuits 14 28.6%

              Nystagmus 10 20.4%

              Need for walking aid 8 18.2%

Pyramidal system

              Hyperreflexia 23 46.9%

              Spasticity 9 18.4%

              Extensor plantar 4 8.2%

Extrapyramidal system

              Rigidity 7 14.2%

              Bradykinesia 15 30.6%

              Chorea 1 2%

              Dystonia 4 8.2%

Abbreviations: UL- Upper Limb, DTR- deep Tendon Reflexes.