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. 2022 Apr 12;13(4):675. doi: 10.3390/genes13040675

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Geographical distribution of three recurrent variants by proband ZIP code. (a) Three probands with variant-specific haplotypes (Hap15) tightly cluster (blue inset); one proband with the same RS1 variant shared 2/7 haplotype markers (gray). (b) Twelve probands with variant-specific haplotypes are in blue (Hap4); one proband with the same RS1 variant shared 6/7 haplotype markers (gray). (c) Six probands with variant specific haplotypes are in blue (Hap5), and one proband shared 6/7 haplotype markers (gray).