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. 2022 Mar 23;10(4):754. doi: 10.3390/biomedicines10040754

Figure 2.

Figure 2

Changes in lipoprotein particle size during CER-001 treatment as determined by Lipoprint analysis. LDL and HDL subclasses were separated from 25 μL of plasma by non-denaturing non-reducing electrophoresis according to particle size. (a) Lipoprint analysis of small and large LDL particles. After the first 2 injections of CER-001, small LDL particles were no longer detectable during the rest of the treatment period (100% of large LDL particles). (b–g) Lipoprint analysis of HDL fractions. Kinetics of HDL particle size changes during CER-001 treatment, showing (b) large, (d) intermediate, and (f) small HDL fractions. Comparison before and 3 h after CER-001 injections (c,e,g). A paired t-test was performed to compare the percentages of large HDLs, intermediate HDLs, and small HDLs before (0 h) and 3 h after CER-001 injection, * p < 0.0332 and ns p > 0.05.