Table 1.
Human leukocyte antigens (HLA) gene polymorphisms related to chronic and aggressive periodontitis.
| Gene | Position | Periodontitis | Race | Type of Study | References |
|---|---|---|---|---|---|
| HLA | DRB1*1501–DQB1*0602 | Positively associated with AgP | - | review | [10] |
| HLA | B*57, DQB1*08, DRB1*04, DRB4*, DQB1*0302 | Negatively associated with AgP and CP | German with Caucasian descent | a case control study | [24] |
| HLA | DR4 (subtypes 0401, 0404, 0405, 0408) | Positively associated with AgP | The ethno-geographic origin of the subjects was neutralized by stratified analysis | a case control study | [25] |
| HLA | DRB1*1401, DRB1*1501, DQB1*0503, DQBA*0602 | Positively associated with AgP | Japanese | a case control study | [26] |
| HLA | A9, B15 A2, B5 |
Susceptibility factors for AgP Protective factors against AgP |
Caucasian | meta-analysis | [27] |
AgP—aggressive periodontitis; CP—chronic periodontitis.