Table 2.
Matrix metalloproteinases (MMPs) gene polymorphisms related to chronic and aggressive periodontitis.
| Gene | Position | Periodontitis | Race | Type of Study | References |
|---|---|---|---|---|---|
| MMP-1 | −1607 1G/2G, −519 A/G, −422 A/T | No associated with the susceptibility to periodontitis | Caucasian, Asian, or mixed (excluding the detailed ethnic results of mixed population in the original study) | meta-analysis | [22] |
| MMP-2 | −1575 G/A, −1306 C/T, −790 T/G, −735 C/T | ||||
| MMP-3 | −1171 5A/6A | ||||
| MMP-8 | −381 A/G, +17 C/G | ||||
| MMP-9 | −1562 C/T, +279 R/Q | ||||
| MMP-12 | −357 Asn/Ser | ||||
| MMP-13 | −77 A/G, 11A/12A | ||||
| MMP-1 | −519 A/G, −422 A/T | No associated with CP | Czech | a case control study | [48] |
| −1607 1G | Increased frequency of CP | ||||
| MMP-2 | −790 T, −790 TT, −790 T/G | Less susceptible to CP | Taiwanese | a case control study | [49] |
| −1562 T | Less susceptible to AgP | ||||
| MMP-2 | −753 C > T | No associated with periodontitis in overall population | Caucasians, Asians, Latinos | meta-analysis | [50] |
| MMP-9 | −1562 C > T | ||||
| MMP-2 | −753 C > T | Associated with periodontitis in Asians | |||
| MMP-9 | −1562 C > T | Associated with periodontitis in Caucasians |
AgP—aggressive periodontitis; CP—chronic periodontitis.