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. 2022 Apr 8;23(8):4146. doi: 10.3390/ijms23084146

Figure 4.

Figure 4

Lysosome-associated protein involves in TRPV4 mediated cell exocytosis. (A) Western blot of cell lysates probed for LAMP2 upon GSK1016790A (20 nM) in A375 cell as well as shTRPV4 A375 cells. Target protein quantification was normalized to total protein. (B) Confocal microscopy images of A375 cells immunostained for LAMP2. Scale bar, 25 μm. (C) Transmission electron microscopic images of lysosomes in cell supernatant upon GSK1016790A (20 nM) application. Scale bar as indicated in figure. Data are presented as mean ± SD of at least three independent experiments, t-test, * p < 0.05, ** p < 0.01, *** p < 0.001, ns indicates no significance.